Volume 10 - پاییز و زمستان86-                   mjms 2008, 10 - پاییز و زمستان86-: 59-64 | Back to browse issues page

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Jokar M, Mahmoodi M, Hesari S, Sobhani M. Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis. mjms 2008; 10 :59-64
URL: http://mjms.modares.ac.ir/article-30-9429-en.html
Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis
Mohammadhassan Jokar 1, Mahmood Mahmoodi2 , Sara Hesari3 , Mansooreh Sobhani3
1- Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3- Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (5231 Views)
Objective: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting rheumatoid arthritis (RA) development and progression. We assessed the diagnostic value of anti-CCP antibodies in our patients with RA. Materials and Methods: Anti-CCP antibodies and rheumatoid factor (RF) titers were determined in 247 serum samples: 128 from RA patients, 119 from control group (48 from healthy controls, 71 from patients with rheumatic disease other than RA or hematologic malignancies). Results: There were 128 (93 females, 35 males) patients with rheumatoid arthritis and 119 (78 females, 41 males) controls. The sensitivity of Anti-CCP was 66.40% for diagnosis of RA with a specificity of 94.11%. The sensitivity of RF was 69.53% and its specificity was 81.51%. Conclusion: In our patients Anti-CCP has a moderate sensitivity but high specificity for diagnosis of RA.
Keywords: Anti-CCP, Anti-CCP, Rheumatoid Arthritis, Rheumatoid factor
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Received: 2007/12/5 | Accepted: 2007/12/31
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