Volume 12, Issue 2 (2009)
mjms 2009, 12(2): 37-49 |
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Jamali S, Emtiazjoo M, Toolabee L, Zeinali S, keypour S, Sardari S, et al . Antibacterial effect of the Persian Gulf sea cucumber Holoturia. SP extracts on three strain of Escherichia coli. mjms 2009; 12 (2) :37-49
URL: http://mjms.modares.ac.ir/article-30-8034-en.html
URL: http://mjms.modares.ac.ir/article-30-8034-en.html
Somayeh Jamali1 
, Mozhgan Emtiazjoo 2, Ladan Toolabee3 , Sirous Zeinali4 , Sepideh Keypour2 , Soroush Sardari5 , Ali Ramezani6 , Parisa Azarang7
, Mozhgan Emtiazjoo 2, Ladan Toolabee3 , Sirous Zeinali4 , Sepideh Keypour2 , Soroush Sardari5 , Ali Ramezani6 , Parisa Azarang7
1- Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
2- Department of Marine Biology, Faculty of Marine Sciences and Technology, Azad Islamic University, North Tehran Branch Tehran, Iran
3- Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
4- Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Department of Genetics, Kawsar Human Genetics Research Center, Tehran, Iran
5- Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
6- Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, , Iran
7- of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
2- Department of Marine Biology, Faculty of Marine Sciences and Technology, Azad Islamic University, North Tehran Branch Tehran, Iran
3- Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
4- Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Department of Genetics, Kawsar Human Genetics Research Center, Tehran, Iran
5- Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
6- Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, , Iran
7- of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Abstract: (5457 Views)
Objective: Sea cucumber is a traditional food and medical item and has been reported to exhibit Antioxidant, antifungal, anti tumoral and antibacterial bioactivity. The objective of this study is to describe the antibacterial activity of 4 extracts of Holoturia. Sp (sea cucumber), collected from Hengam Island of Persian Gulf.
Materials and Methods: Methanol, hexane, aqueous and chloroform extracts from body wall tissue of the sea cucumber were screened for antibacterial activity against three strains of Escherichia coli Top 10 F´, TG1 and K12 using disc diffusion and broth microdilution tests methods.
Result: The growth of all these strains were inhibited using concentration from 0.78 to 100 mg/ml of methanol, hexan and chloroform extracts. Among the extracts just methanol and chloroform with 100 mg/ml had bactericidal effect on TG1 and K12 strains. On the other hand, Aqueous extract had induced growth in of the all strains.
Conclusion: The results suggest the possibility of applying sea cucumber as source of potential anti bacterial agents, whose compounds can be good candidates to make antibiotic products.
Received: 1901/12/14 | Accepted: 1901/12/14
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