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Objective: The entry of Toxoplasma gondii into the bloodstream and other tissues (such as liver, muscle, cardiac muscle, …) of intermediate hosts and its multiplication in nucleated cells may cause changes in plasma levels of various enzymes due to tissue damage. In present study the serum levels of AST, ALT, ALK/P, CPK, LDH, and ACP in rats infected experimentally with Toxoplasma gondii have been investigated. Materials and Methods: Totally, 116 uninfected rats were divided into 87 as case group and 29 as control group. The case group was infected intraperitoneally with 50000 tachyzoites. Blood specimens were taken from cases and its control once every 8 hours in the first three days and then once every three days for a period of 60 days and serum levels were measured for the mentioned enzymes. Results: During the study, the following changes were observed: AST in the first 8 hours, from the 32th hour till the 40th hour and from the 48th hour till the 56th hour; ALT in the first 8 hours and from the 48th hour till the 56th hour; ALK/P from the 24th hour till the 40th hour and from the 48th hour till the 64th hour; CPK and LDH from the 24th hour till the 40th hour and from the 48th hour till 56th hour; ACP from the 16th hour till the 48th hour. But afterward, whole offer mentioned enzyme shifted to normal levels. Conclusion: Alteration in serum enzyme levels of rats during infection with Toxoplasma gondii found is not permanent.

Keywords: Toxoplasma gondii, Rat, Serum enzyme

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