%0 Journal Article %A Sadeghipour, Hamidreza %A Fanaei, Hamed %A Halvaei, Iman %A Sedighi Gilani, Mohammad Ali %A Hajati, Fateme %A Kasaeian, Amir %T Evaluation of the relationship between anti-Müllerian hormone, inhibin-b, testosterone, and semen parameters in cryptorchidism patients %J Pathobiology Research %V 20 %N 4 %U http://mjms.modares.ac.ir/article-30-6781-en.html %R %D 2018 %K Anti-Müllerian Hormone, Inhibin B, Testosterone, Cryptorchidism, %X Objective: Cryptorchidism is the most common deficiency of the male reproductive system and most prevalent endocrine disease of boys at birth. Insufficient prenatal anti-Müllerian hormone (AMH) secretion from Sertoli cells of the testis is one of its causes. The role of this hormone and inhibin B in fertility has recently been proven. AMH is a known indicator of Sertoli cell function. The aim of this study was to assess the relationship between anti-Müllerian hormone, inhibin B, testosterone, and semen parameters in post-pubertal cryptorchidism patients. Methods: We gathered the data of this cross-sectional study from blood and semen samples of 20 patients who had a history of unilateral cryptorchidism. Patients, 20-40 years of age, referred to the Urology Ward of Shariati Hospital, Tehran, Iran. Serum levels of AMH, inhibin B and testosterone were analyzed by enzyme-linked immunosorbent assay. Semen analysis was performed by means of a computer aided semen analysis system 6.5.0. Pearson’s correlation test was used to evaluate the relationships between variables. Result: Significant positive relationships were existed between total sperm motility and sperm concentration (r=0.086; p<0.01), total motility and fast progressive motility (r=0.97; p<0.01), sperm concentration and fast progressive motility (r=0.9; p<0.01), white blood cell count and sperm concentration (r=0.63; p<0.05), white blood cell count and sperm motility (r=0.66; p<0.05), white blood cell count and sperm fast progressive motility (r=0.77; p<0.01), and testosterone levels and serum AMH (r=0.6; p<0.01). Conclusion: Cryptorchidism patients in this study had lower serum concentrations of AMH, inhibin B and testosterone than the normal limits. Despite the positive correlation between serum testosterone and AMH, none of the investigated hormones showed any significant relationship with semen parameters. %> http://mjms.modares.ac.ir/article-30-6781-en.pdf %P 67-76 %& 67 %! Relationship between Anti-Müllerian Hormone, Inhibin-B, Testosterone and Semen Parameters in Cryptorchidism Patients %9 %L A-30-12737-1 %+ (گروه فیزیولوژی) دانشگاه علوم پزشکی تهران %G eng %@ 2538-3000 %[ 2018