Tarbiat Modares University Pathobiology Research 2538-3000 12 2 2009 06 01 Antibacterial effect of the Persian Gulf sea cucumber Holoturia. SP extracts on three strain of Escherichia coli اثر ضد باکتریایی عصاره‌های طبیعی خیار دریایی خلیج فارس Holoturia. SP بر سه سویه از باکتری اشرشیاکلی 37 49 19001 EN Somayeh Jamali Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Mozhgan Emtiazjoo Department of Marine Biology, Faculty of Marine Sciences and Technology, Azad Islamic University, North Tehran Branch Tehran, Iran Ladan Toolabee Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Sirous Zeinali Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Department of Genetics, Kawsar Human Genetics Research Center, Tehran, Iran Sirous Zeinali Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Department of Genetics, Kawsar Human Genetics Research Center, Tehran, Iran Sepideh Keypour Department of Marine Biology, Faculty of Marine Sciences and Technology, Azad Islamic University, North Tehran Branch Tehran, Iran Soroush Sardari Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Ali Ramezani Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, , Iran Parisa Azarang of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Journal Article Objective: Sea cucumber is a traditional food and medical item and has been reported to exhibit Antioxidant, antifungal, anti tumoral and antibacterial bioactivity. The objective of this study is to describe the antibacterial activity of 4 extracts of Holoturia. Sp (sea cucumber), collected from Hengam Island of Persian Gulf. Materials and Methods: Methanol, hexane, aqueous and chloroform extracts from body wall tissue of the sea cucumber were screened for antibacterial activity against three strains of Escherichia coli Top 10 F´, TG1 and K12 using disc diffusion and broth microdilution tests methods. Result: The growth of all these strains were inhibited using concentration from 0.78 to 100 mg/ml of methanol, hexan and chloroform extracts. Among the extracts just methanol and chloroform with 100 mg/ml had bactericidal effect on TG1 and K12 strains. On the other hand, Aqueous extract had induced growth in of the all strains. Conclusion: The results suggest the possibility of applying sea cucumber as source of potential anti bacterial agents, whose compounds can be good candidates to make antibiotic products. https://mjms.modares.ac.ir/article_19001_5f2150c49f5aa191fdee5f8d26c3e50e.pdf