Tarbiat Modares University Pathobiology Research 2538-3000 19 4 2017 09 01 The Effect of Eight Weeks of Aerobic Training on Leptin, Interlukin-6, and Tumor Necrosis Factor-alpha Levels in Inactive Elderly Women تأثیر هشت هفته تمرین هوازی بر سطوح لپتین، اینترلوکین-6 و عامل نکروز‌دهنده آلفا زنان سالمند غیرفعال 13 25 19288 EN Mehdi Doostdar Department of Exercise Physiology, Mashhad branch of Islamic Azad University, Mashhad, Iran Mehrdad Fathei Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran Keyvan Hejazi Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran Mojtaba Kiani Gol Department of Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran Journal Article <strong>Objective: </strong>Atherosclerosis is the most common cause of coronary heart disease and a major cause of ischemic heart diseases. We have investigated the effect of eight weeks of aerobic training on the serum levels of leptin, IL-6, and TNF-α in inactive elderly women. <strong>Methods</strong>: In this semi-experimental study, participants were selected by convenience sampling. We divided 21 subjects into two groups - active (n=10) and non-active (n=11). The program training included 60 min per session, 3 times per week for 8 weeks of aerobic exercise with 50-70 HRR%. Blood samples were taken before and after 8 weeks of aerobic training. We used the t-test for dependent and independent samples for intra- and intergroup comparisons. For all statistical comparisons, the level of significance was set at P<0.05. <strong>Results</strong>: The aerobic training groups had a significant reduction in leptin (P=0.001), IL-6 (P=0.01), and TNF-α (P=0.001) after 8 weeks of aerobic training compared with the control group. The intergroup variations in weight, BMI, leptin, and TNF-α had a significant change (P<0.05). <strong>Conclusion</strong>: The results of the present study suggested that endurance training decreased leptin, IL-6, and TNF-α levels, effectively improved cardiovascular health, and reduced the risk of atherosclerosis. https://mjms.modares.ac.ir/article_19288_87f8e1e0156138cca3206c48b7098f41.pdf