Tarbiat Modares University Pathobiology Research 2538-3000 20 4 2018 12 01 Evaluation of the relationship between anti-Müllerian hormone, inhibin-b, testosterone, and semen parameters in cryptorchidism patients بررسی ارتباط هورمون‏های آنتی مولرین، اینهیبین B و تستوسترون با شاخص‏های مایع منی در بیماران کریپتورکیدیسم 67 76 19314 EN Hamidreza Sadeghipour (گروه فیزیولوژی) دانشگاه علوم پزشکی تهران Hamed Fanaei Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Iman Halvaei Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Mohammad Ali Sedighi Gilani Department of Urology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Fateme Hajati Department of Anatomical sciences, Faculty of Medical sciences, Tarbiat Modares University, Tehran, Iran Amir Kasaeian Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Journal Article <strong>Objective: </strong>Cryptorchidism is the most common deficiency of the male reproductive system and most prevalent endocrine disease of boys at birth. Insufficient prenatal anti-Müllerian hormone (AMH) secretion from Sertoli cells of the testis is one of its causes. The role of this hormone and inhibin B in fertility has recently been proven. AMH is a known indicator of Sertoli cell function. The aim of this study was to assess the relationship between anti-Müllerian hormone, inhibin B, testosterone, and semen parameters in post-pubertal cryptorchidism patients. <strong>Methods</strong>: We gathered the data of this cross-sectional study from blood and semen samples of 20 patients who had a history of unilateral cryptorchidism. Patients, 20-40 years of age, referred to the Urology Ward of Shariati Hospital, Tehran, Iran. Serum levels of AMH, inhibin B and testosterone were analyzed by enzyme-linked immunosorbent assay. Semen analysis was performed by means of a computer aided semen analysis system 6.5.0. Pearson’s correlation test was used to evaluate the relationships between variables. <strong>Result</strong>: Significant positive relationships were existed between total sperm motility and sperm concentration (r=0.086; p<0.01), total motility and fast progressive motility (r=0.97; p<0.01), sperm concentration and fast progressive motility (r=0.9; p<0.01), white blood cell count and sperm concentration (r=0.63; p<0.05), white blood cell count and sperm motility (r=0.66; p<0.05), white blood cell count and sperm fast progressive motility (r=0.77; p<0.01), and testosterone levels and serum AMH (r=0.6; p<0.01). <strong>Conclusion</strong>: Cryptorchidism patients in this study had lower serum concentrations of AMH, inhibin B and testosterone than the normal limits. Despite the positive correlation between serum testosterone and AMH, none of the investigated hormones showed any significant relationship with semen parameters. https://mjms.modares.ac.ir/article_19314_a8de36128c9564d44a4b6d66d602e4cd.pdf