Tarbiat Modares University Pathobiology Research 2538-3000 22 1 2018 12 01 Differentiation and Apoptosis in Mammalian Germ Cellslls تمایز و آپوپتوز در سلول‌های زایای پستانداران 51 61 19342 EN M. Salem Biology Department, Sciences Faculty, University of Mohaghegh Ardabili, Ardabil, Iran T. Mirzapour Biology Department, Sciences Faculty, University of Guilan, Rasht, Iran A. Bayrami Biology Department, Sciences Faculty, University of Mohaghegh Ardabili, Ardabil, Iran M. Movahedin Anatomical Science Department, Medical Science Faculty, Tarbiat Modrres University, Tehran, Iran Journal Article Primordial germ cells (PGCs) are the specialized cells that are created from epiblast cells and after the migration differentiate into spermatogonial cells. Also, Spermatogonial cells differentiate into spermatids during the spermatogenesis process. Created disorders in each of these stages cause infertility, so the recognizing of the mechanism of these cells from the early stages of formation to the differentiation and investigating the effective factors in differentiation can be useful in the treatment of the infertile people. Today, the cultivation of spermatogonial cells and transplantation of these cells can be effective in the investigation of spermatogonial stem cell and the treatment of infertility. In this paper, the formation and migration of primordial germ cells, the spermatogenesis process and the effective factors in differentiation of spermatogonial stem cells are investigated.<strong><span dir="RTL"></span></strong> https://mjms.modares.ac.ir/article_19342_e168a388110e81537d5be2a524f9b79a.pdf