Tarbiat Modares University Pathobiology Research 2538-3000 23 4 2020 06 01 Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications معرفی فرم اینتگره شده هرپس ویروس انسانی 6 و پیامدهای بالینی آن: مقاله مروری-روایتی 55 66 19391 EN Somayeh Shatizadeh Malekshahi Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University,Tehran, Iran Kiana Ketabi Department of Virology, Faculty of Medical Sciences, TarbiatModares University,Tehran, Iran Journal Article <strong>Aims:</strong> Human herpes virus 6 (HHV-6) is a ubiquitous virus with a high rate of prevalence worldwide. In recent years, a new form of the virus genome has been identified called <span dir="LTR">Chromosomally integrated HHV-6 (ciHHV-6)</span>. Further studies are required to elucidate the relation between ciHHV-6 and other clinical complications. The purpose of this study was to summarize the literature on different clinical aspects of the ciHHV-6 integration and its prevalevce in different communities.<br> <strong>Materials and methods:</strong> Search keywords include HHV-6, integrated genome, telomeric regions and integrated HHV-6. Scientific databases such as scopus, PubMed and google scholar with no specified start date were used for information collection.<br> <strong>Findings: </strong>About 1% of global populations are infected with ciHHV-6. Real-time PCR can be used to differentiate between ciHHV-6 and HHV-6 acute infection in which the viral load will be higher in ciHHV-6 compared to the acute infection. However, ciHHV-6 can be confirmed by evidence of one copy of viral DNA in hair or nail follicles. It has been shown that ciHHV-6 may disrupt the telomer stability.<br> <strong>Conclutions:</strong> To date, no treatment has been discovered to remove the viral genome from the host cells. Taken together, the integrated form of the HHV-6 genome could be linked to the various diseases, including heart and autoimmune diseases. But further studies are needed to find its association with other diseases in different geographic area. https://mjms.modares.ac.ir/article_19391_6ecee9c863a73e2c3ba55b5fc99b1fed.pdf