Tarbiat Modares University Pathobiology Research 2538-3000 25 3 2022 04 01 Impact of Maternal Separation on Long-Term Potentiation and Synaptic Plasticity: Insights from Rodent Models 36 39 19453 EN Fateme Pishgooei Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Saeed Mehrazin Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Khadijeh Esmaeilpour Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Journal Article <span>Maternal separation (MS) is a well-characterized model of early life stress, based on the postnatal disruption of the mother-infant interaction. Studies on rodents have demonstrated that MS, as an early adverse life event, leads to spatial memory deficits and lasting changes in brain plasticity. Here, we review data from animal studies regarding the impact of MS on long-term potentiation (LTP). Evidence shows that animal models are useful for evaluating the effects of MS on LTP. Overall, studies suggest that MS impairs LTP.</span><br> https://mjms.modares.ac.ir/article_19453_05180a6ec799ff23dabad1f899382570.pdf