Tarbiat Modares University Pathobiology Research 2538-3000 29 2 2026 06 01 Improvement of myeloperoxidase and high-density lipoprotein following silymarin supplementation during aerobic training in adult obese women with metabolic syndrome 15 21 28739 10.48311/mjms.2026.119853.82622 EN Narges Shirzadian Department of Exercise Physiology, Isl.C., Islamic Azad University, Islamshahr, Iran Sanaz Mirzayan Shanjani Department of Exercise Physiology, Isl.C., Islamic Azad University, Islamshahr, Iran Saeed Ghorbani Department of Sport Science, Isl.C., Islamic Azad University, Islamshahr, Iran Yaser Kazemzadeh Department of Exercise Physiology, Isl.C., Islamic Azad University, Islamshahr, Iran Journal Article 2026 04 18 Introduction: Recently, the role of antioxidant supplements during aerobic training has been highlighted to improve cardiovascular function in chronic metabolic diseases. In the present study, the effect of aerobic training with and without silymarin supplementation on myeloperoxidase (MPO) and High Density Lipoprotein (HDL) was evaluated in women with metabolic syndrome.<br>Methods: For this purpose, 48 adult females aged 30-40 years of old (30≤BMI≤36) with metabolic syndrome were randomly divided into control (no training), exercise (aerobic training, 8 weeks, 3 sessions/weekly), supplement (silymarin supplementation, 8 weeks, 280mg/daily) and combine (aerobic training+ silymarin). Fasting blood samples were collected before and 48 hours after lasting exercise session with regard to measuring serum MPO and HDL. Data were compared between groups using ANCOVA and Bonferroni Post-Hoc test (p≤0.05). <br>Results: Compared to control group, fasting HDL significantly increased in 3 intervention groups (p<0.05). Aerobic training with and without silymarin supplementation resulted in a significant decrease in MPO compared to the control group (p=0.017, p<0.05 respectively). Silymarin consumption alone did not affect MPO compared to the control group (p=0.999). Compared to the exercise and supplement groups, serum MPO was significantly deceased and HDL significantly increased in combined group (p<0.05).<br>Conclusion: With the conclusion from this article, aerobic training with and without silymarin supplementation leads to increased HDL in women with metabolic syndrome. This improvement may be attributed to a decrease in MPO in response to these interventions. Understanding the underlying mechanisms responsible for these changes requires further studies in this area. https://mjms.modares.ac.ir/article_28739_ecc1d44b677d62d29e0f646131316ca6.pdf