دوره 24، شماره 1 - ( 1400 )                   جلد 24 شماره 1 صفحات 63-71 | برگشت به فهرست نسخه ها

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Nouri M, Yahyaei B, Najafalipour F. Evaluation of the Effects Due to Injection of Biological Magnetic Iron Nanoparticles in Ovarian Tissue of Female Wistar Rats in Response to Electromagnetic Field. mjms. 2021; 24 (1) :63-71
URL: http://mjms.modares.ac.ir/article-30-52840-fa.html
یحیایی بهروز. Evaluation of the Effects Due to Injection of Biological Magnetic Iron Nanoparticles in Ovarian Tissue of Female Wistar Rats in Response to Electromagnetic Field. Pathobiology Research. 1400; 24 (1) :63-71

URL: http://mjms.modares.ac.ir/article-30-52840-fa.html


1- گروه پزشکی، واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران ، behroozyahyaei@yahoo.com
چکیده:   (234 مشاهده)
Introduction: In this study, we investigated the accumulation and tissue effects due to injection of biological magnetic iron nanoparticles in the ovarian tissue of Wistar rats in response to electromagnetic field by inductively coupled plasma (ICP) and histopathological methods.
Methods: In this experimental study, the animals were classified in groups of four as follows: Group of healthy female rats receiving nanoparticles with non-toxic dose in absence of  electromagnetic field, group of healthy female rats without receiving nanoparticles and in absence of  electromagnetic field (control group), group of healthy female rats receiving nanoparticles with non-toxic dose in presence of an electromagnetic field and group of healthy female rats without receiving nanoparticles in presence of an electromagnetic field. After grouping the rats, the biological nanoparticles were injected intraperitoneally and an electromagnetic field was created on the skin of the rats at the site of the ovaries, which were fixed using tape. Then, by ICP analysis, we examine the presence of iron nanoparticles in the tissue.
Results: Magnetic iron nanoparticles had low toxicity so that its half-maximal inhibitory concentration (IC50) value in well number 1 was 0.386. In the two groups of non-toxic doses of nanoparticles in presence or in absence of electromagnetic field, No changes were observed for primary and secondary follicles, as well as connective tissue and blood.
Conclusion: Magnetic iron nanoparticles have no destructive effects on ovarian tissue and have low cell accumulation and therefore their use in this field was recommended to improve the future treatment of ovarian cancer.
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نوع مقاله: پژوهشي اصيل | موضوع مقاله: فناوری نانو
دریافت: 1400/3/5 | پذیرش: 1400/4/26
* نشانی نویسنده مسئول: شاهرود. دانشگاه آزاد اسلامی. دانشکده علوم پزشکی

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