Volume 26, Issue 2 (2023)                   mjms 2023, 26(2): 7-15 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Farhadi Kia A, Shojaei A, Ghafouri S. Involvement of hippocampus in learning and memory through associated synaptic plasticity: the role of glutamate and GABA receptors. mjms 2023; 26 (2) :7-15
URL: http://mjms.modares.ac.ir/article-30-64876-en.html
Involvement of hippocampus in learning and memory through associated synaptic plasticity: the role of glutamate and GABA receptors
Arta Farhadi Kia1 , Amir Shojaei2 , Samireh Ghafouri 3
1- Faculty of medicine, Izmir University of Economics
2- Tarbiat Modares University of Medical Sciences
3- Ahvaz Jundishapur University of Medical Sciences , samireh.ghafouri@gmail.com
Abstract:   (5361 Views)
Synaptic plasticity is one of the most crucial physiological processes involved in learning and memory. Diseases such as Alzheimer’s, depression, and epilepsy, which affect synaptic plasticity, lead to memory and learning impairments. The hippocampus is a key brain region in synaptic plasticity. Neural plasticity is a complex process dependent on neurochemical underpinnings. Next to the glutamatergic system which contributes to memory formation via long-term potentiation (LTP) and long-term depression (LTD), the main inhibitory neurotransmitter, GABA is crucially involved in neuroplastic processes. Therefore, understanding the mechanisms which are involved in the synaptic plasticity and memory processes can help us to overcome neurological disease which they affect memory function and synaptic plasticity.
 
Keywords: Hippocampus, Synaptic plasticity, Long-term potentiation, Long-term depression, Depotentiation
Full-Text [PDF 934 kb]   (4276 Downloads)    
Article Type: Systematic Review | Subject: Cellular and Molecular Neuroscience
Received: 2022/10/17 | Accepted: 2024/07/31
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.