Volume 14, Issue 2 (2011)                   mjms 2011, 14(2): 75-82 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asheghabadi M, Bigdeli M R. The role of oxygen radicals-scavenger in neuroprotection-induced by normobaric hyperoxia on infarct volume in the rat brain. mjms. 2011; 14 (2) :75-82
URL: http://mjms.modares.ac.ir/article-30-7630-en.html
1- M.Sc., Department of Physiology, Faculty of Biological Sciences, Beheshti University, Iran
2- Asisstant Professor, Department of Physiology, Faculty of Biological Sciences, Beheshti University, Iran
Abstract:   (4541 Views)
Objective: Recent studies have shown that the use of prolonged and intermittent normobaric hyperoxia (95%) decrease the infarct volume of stroke. The aim of current study was to study the effect of an oxygen radicals-scavenger applied during intermittent normobaric hyperoxia on infarct volume in the rat brain and neurologic deficit. Materials and Methods: Male Wistar rats (250-350 g) were divided to two main groups. These groups were respectively subjected to room air (21% O2; RA) or normobaric hyperoxia (95% O2; HO) 4 hours per day for 6 days. Each main group was divided to three subgroups which received nothing (RA and HO), normal saline (HO-S and RA-S) or Dimethyltiourea (HO-MT and RA-MT. Afterward, all rats were subjected to 60 min middle cerebral artery occlusion (MCAO). After 24 h, neurologic deficit scores and infarct volume were assessed. Results: The medians of neurologic deficit scores in RA, RA-MT, RA-S, HO-MT, HO-S, and HO were 2, 2, 2, 2, 0, 0, respectively. The infarct volume in RA, RA-MT, RA-S, and HO-MT versus HO-S, and HO were increased. Above results showed that neurologic deficit score and infarct volume were restored by MT significantly. Conclusion: The effective neuroprotection induced by intermittent normobaric hyperoxia seems to be mediated at least partially by oxygen radicals.
Full-Text [PDF 497 kb]   (2320 Downloads)    
Article Type: Original Manuscipt | Subject: Patho Biology
Received: 2011/04/18 | Accepted: 2011/07/13

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.