Study role of age in contact dependent transmission of Mycobacterium tuberculosis in northwest of Iran by IS6110-RFLP method

Authors
محمد اصغرزاده
عباس ‌علی‌ بخشی
جواد رنجبری
غلام‌رضا حنیفی
ایرج خلیلی
ناصر رزم‌آرایی
Abstract
Objective: The present study investigated the role in transmission of M. tuberculosis strains isolated from tuberculosis patients residing in Northwest (East and West Azarbaijan) of Iran.
Materials and Methods: We performed restriction fragment length polymorphism analysis on IS6110 of M. tuberculosis isolated from Northwest Iran. Total of 165 isolates of M. tuberculosis were analyzed by RFLP method.
Results: The 5 copies and more IS6110 isolates comprised 30.52% of the total isolates. They formed 16 clustered groups consisting of 2 to 10 cases each. 69.48% of patients had a unique RFLP patterns. Cases from male patients were more clustered than female patients but statistically was not significant (P>0.05). In this study patients with 56 and older age were strongly associated with clustering (59.6%), which were significantly more than younger patients (P<0.05).
Conclusion: In the present study we found old age as a major risk factor in contact dependent transmission of TB compared to disease recurrence. Unemployment and poor living condition were also among the risk factors in transmission of tuberculosis.

Keywords

Pathobiology Reserach
Volume 12, Issue 1
Winter 2009
Pages 11-16