1
Instructor, Department of Microbiology, Immunology and Hematology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2
Professor, Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3
Associated Professor, Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4
Assistant Professor, Department of Hematology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
5
B.Sc., Iranian Blood Transfusion Organization, Rafsanjan Center, Rafsanjan, Iran
Abstract
Objective: Occult hepatitis B infection is a form of hepatitis in which despite of absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. This clinical form of B hepatitis creates some problems for the Iranian blood transfusion services. Therefore, the aim of this study was the evaluation of status of occult hepatitis B infection in the Rafsanjanese blood donors.
Materials and Methods: In this cross-sectional study, total of 3700 blood donor samples were collected and tested for HBsAg and anti-HBs using ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA using PCR.
Results: Results of current study indicated that 352 (9.5%) of 3700 blood samples were HBsAg– and anti-HBc+. HBV-DNA was detected in 57 (16.1% of HBsAg– and anti-HBc+ and 1.54% of total samples) samples.
Conclusion: Results of this study are in agreement with our previous studies in the prevalence of OBI. Therefore, it seems that occult hepatitis B infection rate is high in the Iranian blood donors and probably is one of the main causes of post-transfusion hepatitis.
Kazemi Arababadi,M , Pourfathollah,A A , Jafarzadeh,A , Hassanshahi,G , Afrooz,M R and Hadadian,M . (2008). Occult HBV infection in Rafsanjanese blood donors. Pathobiology Research, 11(0), 1-7.
MLA
Kazemi Arababadi,M , , Pourfathollah,A A , , Jafarzadeh,A , , Hassanshahi,G , , Afrooz,M R , and Hadadian,M . "Occult HBV infection in Rafsanjanese blood donors", Pathobiology Research, 11, 0, 2008, 1-7.
HARVARD
Kazemi Arababadi M, Pourfathollah A A, Jafarzadeh A, Hassanshahi G, Afrooz M R, Hadadian M. (2008). 'Occult HBV infection in Rafsanjanese blood donors', Pathobiology Research, 11(0), pp. 1-7.
CHICAGO
M Kazemi Arababadi, A A Pourfathollah, A Jafarzadeh, G Hassanshahi, M R Afrooz and M Hadadian, "Occult HBV infection in Rafsanjanese blood donors," Pathobiology Research, 11 0 (2008): 1-7,
VANCOUVER
Kazemi Arababadi M, Pourfathollah A A, Jafarzadeh A, Hassanshahi G, Afrooz M R, Hadadian M. Occult HBV infection in Rafsanjanese blood donors. Pathobiology Research. 2008;11(0):1-7.
Pathobiology Research