Study of IgE in children with Steroids Responsive Nephrosis

Objectives: The idiopathic minimal change nephritic syndrome (nephrosis) is responsible in 80% of nephritic syndromes in children. It is a clinical entity characterized by inter and outer renal parameters. Main factor in glomerolar damages is proteinuria and the role of IgE is possible. Aim: In this research, serum IgE concentrations were measured in children with nephrosis in three stages: Relapse, Remission in treatment with steroids, Remissions after treatment with steroids.
Materials and methods: Study was done on children under 16 years old that suffered from nephrosis. They treated with Prednisolone. Serum IgE concentrations were measured by ELISA technique.
Results: Average Concentration of serum IgE in the relapse phase was 274.8 Iu/ml (SD=14.6); It was in the remission with steroids treatments 179.59 Iu/ml (SD= 14.82) and it was 234. 9 Iu/ml (SD=14.58) in the remission phase after treatment with steroids.
Conclusion: In some cases IgE is significantly reduced after steroid treatment therefore it seems possible that allergic agents can trigger or increase the disease. Serum IgE concentration was not a main factor in nephritic syndrome.