Study of IgE in children with Steroids Responsive Nephrosis

Authors
Maryam Keshavarz 1
Farideh Khosravy 2
Behrouz Nikbin 1
Malektaj Honarmand 3
Abdolfatah Sarafnejad 4
1 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Nephrology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Objectives: The idiopathic minimal change nephritic syndrome (nephrosis) is responsible in 80% of nephritic syndromes in children. It is a clinical entity characterized by inter and outer renal parameters. Main factor in glomerolar damages is proteinuria and the role of IgE is possible. Aim: In this research, serum IgE concentrations were measured in children with nephrosis in three stages: Relapse, Remission in treatment with steroids, Remissions after treatment with steroids.
Materials and methods: Study was done on children under 16 years old that suffered from nephrosis. They treated with Prednisolone. Serum IgE concentrations were measured by ELISA technique.
Results: Average Concentration of serum IgE in the relapse phase was 274.8 Iu/ml (SD=14.6); It was in the remission with steroids treatments 179.59 Iu/ml (SD= 14.82) and it was 234. 9 Iu/ml (SD=14.58) in the remission phase after treatment with steroids.
Conclusion: In some cases IgE is significantly reduced after steroid treatment therefore it seems possible that allergic agents can trigger or increase the disease. Serum IgE concentration was not a main factor in nephritic syndrome.
Keywords
IgE
Idiopathic minimal change nephrotic syndrome