Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis

Authors
M. Jokar 1
M. Mahmoodi 2
S. Hesari 3
M. Sobhani 3
1 Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Objective: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting rheumatoid arthritis (RA) development and progression. We assessed the diagnostic value of anti-CCP antibodies in our patients with RA.
Materials and Methods: Anti-CCP antibodies and rheumatoid factor (RF) titers were determined in 247 serum samples: 128 from RA patients, 119 from control group (48 from healthy controls, 71 from patients with rheumatic disease other than RA or hematologic malignancies).
Results: There were 128 (93 females, 35 males) patients with rheumatoid arthritis and 119 (78 females, 41 males) controls. The sensitivity of Anti-CCP was 66.40% for diagnosis of RA with a specificity of 94.11%. The sensitivity of RF was 69.53% and its specificity was 81.51%.
Conclusion: In our patients Anti-CCP has a moderate sensitivity but high specificity for diagnosis of RA.

Keywords

Pathobiology Reserach
Volume 10, Issue 0
February 2008
Pages 59-64