1
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2
Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Objective: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers for rheumatoid arthritis (RA) and useful for predicting rheumatoid arthritis (RA) development and progression. We assessed the diagnostic value of anti-CCP antibodies in our patients with RA.
Materials and Methods: Anti-CCP antibodies and rheumatoid factor (RF) titers were determined in 247 serum samples: 128 from RA patients, 119 from control group (48 from healthy controls, 71 from patients with rheumatic disease other than RA or hematologic malignancies).
Results: There were 128 (93 females, 35 males) patients with rheumatoid arthritis and 119 (78 females, 41 males) controls. The sensitivity of Anti-CCP was 66.40% for diagnosis of RA with a specificity of 94.11%. The sensitivity of RF was 69.53% and its specificity was 81.51%.
Conclusion: In our patients Anti-CCP has a moderate sensitivity but high specificity for diagnosis of RA.
Jokar, M., Mahmoodi, M., Hesari, S. & Sobhani, M. (2008). Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis. Pathobiology Research, 10(0), 59–64.
MLA
Jokar, M., Mahmoodi, M., Hesari, S., & Sobhani, M. "Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis", Pathobiology Research, 10, 0, 2008, 59–64.
HARVARD
Jokar, M., Mahmoodi, M., Hesari, S., & Sobhani, M. (2008). 'Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis', Pathobiology Research, 10(0), pp. 59–64.
CHICAGO
Jokar, M., Mahmoodi, M., Hesari, S. & Sobhani, M., "Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis." Pathobiology Research, 10 0 (2008): 59–64,
VANCOUVER
Jokar M., Mahmoodi M., Hesari S., Sobhani M. Diagnostic value of anti-cyclic citrullinated peptide antibodies in patients with rheumatoid arthritis. Pathobiology Research. 2008;10(0):59–64.
Pathobiology Research