The effects of eight weeks of aerobic interval exercise on omentin-1, resistin, and adiponectin in elderly men with type 2 diabetes

Authors
S. A. Jafari Ghaleh No 1
M. Fathi 2
K. Hejazi 3
M. Ziayi 1
1 Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Bojnourd Branch of Islamic Azad University, Bojnourd, Iran
2 Department of Exercise Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3 Department of Sports Sciences, Toos Institute of Higher Education, Mashhad, Iran
Abstract
Objective: Diabetes is one of the most common glandular diseases worldwide. Diabetics suffer more than other individuals from eye, nerve, and cardiovascular problems, in addition to renal insufficiency. The purpose of this study is to investigate the effects of eight weeks of aerobic interval exercise on omentin-1, resistin, and adiponectin in elderly men with type II diabetes.
Methods: This semi-experimental study was conducted in Bojnourd, Iran in 1395. The study enrolled 24 overweight male patients with type II diabetes mellitus by the convenience sampling method. Patients were randomized to two groups: experimental (n=12) and control (n=12). The experimental group participated in 8 weeks of interval aerobic training (5 days/week at 30-45 min duration with 65%-70% HRR per session). Data were analyzed with the paired sample t-test and MANOVA for comparison of means within and between groups, respectively. The level of significance was set at p≤0.05.
Results: Omentin-1 and adiponectin increased significantly, whereas we observed significantly reduced resistin and HbA1c levels (p<0.05). The average differences in the omentin-1, adiponectin, resistin, and HbA1c levels between the two groups showed statistical significance (p<0.05).
Conclusion: The eight weeks of aerobic interval training led to significantly decreased resistin and HbA1c levels, along with significantly increased omentin-1 and adiponectin levels in men with type 2 diabetes. Good health could be maintained with a proper exercise protocol in these patients. We recommend that new and variety training protocols, especially in elderly and vulnerable people should be investigated.

Keywords

[1]Steinberger J, Daniels SR; American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young); American Heart Association Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 2003; 107(10): 1448-53.
[2]Larejani B, Zahedi F. Epidemiology of diabetes mellitus in iran. IJDLD 2001; 1(1): 1-8. (Persian)
[3]Holt RI, Cockram C, Flyvbjerg A, Goldstein BJ. Textbook of diabetes. USA: Human kinetic, 2017; p: 170-4.
[4]Mahmuda F, Akhter M, Nath RK. Obesity in the Pathogenesis of type 2 Diabetes. KYAMC Journal. 2013; 4(1): 357-61.
[5]Calle EE, Teras LR, Thun MJ. Obesity and mortality. N Engl J Med 2005; 353(20): 2197-9.
[6]Mead JR, Irvine SA, Ramji DP. Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med (Berl) 2002; 80(12): 753-69.
[7]Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, Shikata K, Hourai S, Futami J, Watanabe E, Matsuki Y, Hiramatsu R, Akagi S, Makino H, Kanwar YS. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci U S A 2005; 102(30): 10610-5.
[8]Li Q, Chen R, Moriya J, Yamakawa J, Sumino H, Kanda T, Takahashi T. A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity. J Int Med Res 2008; 36(4): 625-9.
[9]Watanabe T, Watanabe-Kominato K, Takahashi Y, Kojima M, Watanabe R. Adipose Tissue-Derived Omentin-1 Function and Regulation. Compr Physiol 2017; 7(3): 765-781.
[10]Çimen AR, Cerit ET, Iyidir OT, Karakus R, Uyar BB, Toruner FB, Cakir N, Arslan M. Serum omentin-1 levels and endothelial dysfunction in obesity. Acta Endo (Buc) 2017; 13(2): 138-43.
[11]de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC. Omentin plasma levels and gene expression are decreased in obesity. Diabetes 2007; 56(6): 1655-61.
[12]Tekce H, Tekce BK, Aktas G, Alcelik A, Sengul E. Serum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney disease. Exp Clin Endocrinol Diabetes 2014; 122(8): 451-6.
[13]Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol 2004; 24(1): 29-33.
[14]Xu A, Yin S, Wong L, Chan KW, Lam KS. Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology 2004; 145(2): 487-94.
[15]Wiecek A, Adamczak M, Chudek J. Adiponectin--an adipokine with unique metabolic properties. Nephrol Dial Transplant 2007; 22(4): 981-8.
[16]Goralski KB, Sinal CJ. Type 2 diabetes and cardiovascular disease: getting to the fat of the matter. Can J Physiol Pharmacol 2007; 85(1): 113-32.
[17]Aminiaghdam S, Moradi F, Pejhan A, Seyedahmadi M. Survey of relationships between serum adiponectin levels with insulin resistance, blood pressure, and cardiorespiratory function in sedentary men. Journal of Sabzevar University of Medical Sciences 2013; 19(4): 325-35.
[18]Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature 2001; 409(6818): 307-12.
[19]Aksoy DY, Cinar N, Harmanci A, Karakaya J, Yildiz BO, Usman A, Bayraktar M. Serum resistin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxine therapy. Med Sci Monit 2013; 19: 210-5.
[20]Ding Q, White SP, Ling C, Zhou W. Resistin and cardiovascular disease. Trends Cardiovasc Med 2011; 21(1): 20-7.
[21]Zamanpour L, Banitalebi E, Amirhosseini SE. The Effect Of Sprint Training And Combined Aerobic And Strength Training On Some Inflammatory Markers And Insulin Resistance In Women With Diabetes Mellitus (T2dm). IJDLD 2016; 15(5): 300-11.
[22]Alizadeh M, Asad MR, Faramarzi M, Afroundeh R. Effect of Eight-Week High Intensity Interval Training on Omentin-1 Gene Expression and Insulin-Resistance in Diabetic Male Rats. Ann Appl Sport Sci 2017; 5(2): 29-36. (Persian)
[23]Avazpor S, Kalkhoran JF, Amini HA. Effect of 8 Weeks of High Intensity Interval Training on Plasma Levels of Adiponectin and Leptin in Overweight Nurses. Novel Biomed 2016; 4(3): 87-92.
[24]Wilms B, Ernst B, Gerig R, Schultes B. Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training. Exp Clin Endocrinol Diabetes 2015; 123(3): 187-92.
[25]Jamurtas AZ, Theocharis V, Koukoulis G, Stakias N, Fatouros IG, Kouretas D, Koutedakis Y. The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males. Eur J Appl Physiol 2006; 97(1): 122-6.
[26]Afshounpour MT, Habibi A, Ranjbar R. Impact of combined exercise training on plasma concentration of Apelin, resistin and insulin resistance in patients with type 2 diabetics’ male. HMJ 2016; 20(3): 158-69.
[27]Sternfeld B, Ainsworth BE, Quesenberry CP. Physical activity patterns in a diverse population of women. Prev Med 1999; 28(3): 313-23.
[28]Bartlett JE, Kotrlik JW, Higgins CC. Organizational research: Determining appropriate sample size in survey research appropriate sample size in survey research. Information Technology, Learning, and Performance Journal 2001; 19(1): 43-50.
[29]Kim JS, Lee YH, Kim JC, Ko YH, Yoon CS, Yi HK. Effect of exercise training of different intensities on anti-inflammatory reaction in streptozotocin-induced diabetic rats. Biol Sport 2014; 31(1): 73-9.
[30]Kamel SR, Sadek HA, Mohamed FA, Ali LH, Osman HM. Differences in body mass index, waist circumference, and waist-to-hip ratio in patients with rheumatoid arthritis: association with serum adiponectin and disease parameters. Egypt Rheumatol Rehabil 2017; 44: 24-9.
[31]Terada T, Friesen A, Chahal BS, Bell GJ, McCargar LJ, Boulé NG. Feasibility and preliminary efficacy of high intensity interval training in type 2 diabetes. Diabetes Res Clin Pract 2013; 99(2): 120-9.
[32]Ouerghi N, Ben Fradj MK, Bezrati I, Feki M, Kaabachi N, Bouassida A. Effect of High-Intensity Interval Training on Plasma Omentin-1 Concentration in Overweight/Obese and Normal-Weight Youth. Obes Facts 2017; 10(4): 323-31.
[33]Nasrabadi M, Mogharnasi M. Effect of rhythmic aerobic exercise on serum concentration of omentin-1 and same anthropometric markers in obese women. IJDLD 2017; 15(3): 192-200. (Persian)
[34]Banitalebi E, Mardanpour Shahrekordi Z, Kazemi AR, Bagheri L, Amani Shalamzari S, Faramarzi M. Comparing the Effects of Eight Weeks of Combined Training (Endurance and Resistance) in Different Orders on Inflammatory Factors and Adipokines Among Elderly Females, Women Health Bull 2016; 3(2): e30990.
[35]Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006; 290(6): E1253-61.
[36]Moreno-Navarrete JM, Catalán V, Ortega F, Gómez-Ambrosi J, Ricart W, Frühbeck G, Fernández-Real JM. Circulating omentin concentration increases after weight loss. Nutr Metab (Lond) 2010; 7: 27.
[37]Bremer AA, Jialal I. Adipose tissue dysfunction in nascent metabolic syndrome. J Obes 2013; 2013: 393192.
[38]Kazama K, Usui T, Okada M, Hara Y, Yamawaki H. Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells. Eur J Pharmacol 2012; 686(1-3): 116-23.
[39]Tan BK, Adya R, Farhatullah S, Chen J, Lehnert H, Randeva HS. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome. Diabetes 2010; 59(12): 3023-31.
[40]Herder C, Ouwens DM, Carstensen M, Kowall B, Huth C, Meisinger C, Rathmann W, Roden M, Thorand B. Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study. Eur J Endocrinol 2015; 172(4): 423-32.
[41]Smitka K, Marešová D. Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment. Prague Med Rep 2015; 116(2): 87-111.
[42]Tan BK, Adya R, Farhatullah S, Lewandowski KC, O'Hare P, Lehnert H, Randeva HS. Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose. Diabetes 2008; 57(4): 801-8.
[43]Jamali E, Asad MR, Rasoli A. The effect of high-intensity interval training (HIIT) on resistin gene expression in visceral adipose tissue in obese male rats. International Journal of Applied Exercise Physiology 2016; 5(1): 17-25.
[44]Hajirasouli M, Hajirasouli M, Afsharmand Z. Effect of a Chronic Aerobic Training on Adipocytokine Resistin in Smokers. Biological Forum 2014; 6(2): 530-4.
[45]Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, Fallucca S, Alessi E, Letizia C, Jimenez A, Fallucca F, Pugliese G. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010; 20(8): 608-17.
[46]Donnelly JE, Smith B, Jacobsen DJ, Kirk E, Dubose K, Hyder M, Bailey B, Washburn R. The role of exercise for weight loss and maintenance. Best Pract Res Clin Gastroenterol 2004; 18(6): 1009-29.
[47]Kwon H, Pessin JE. Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) 2013; 4: 71.
[48]Verma S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, Mickle DA. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 2003; 108(6): 736-40.
[49]Pourvaghar MJ, Bahram ME, Sayyah M, Khoshemehry S. The Effects of Three Months of HIIT on Plasma Adiponectin on Overweight College Men. World Academy of Science, Engineering and Technology: International Journal of Sport and Health Sciences 2017; 11(8): 437-40.
[50]Jeon JY, Han J, Kim HJ, Park MS, Seo DY, Kwak YS. The combined effects of physical exercise training and detraining on adiponectin in overweight and obese children. Integrative Medicine Research 2013; 2(4): 145-50.
[51]Duncan BB, Schmidt MI, Pankow JS, Bang H, Couper D, Ballantyne CM, Hoogeveen RC, Heiss G. Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 2004; 53(9): 2473-8.
[52]Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001; 50(5): 1126-33.
[53]Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T. Adiponectin receptors: a review of their structure, function and how they work. Best Pract Res Clin Endocrinol Metab 2014; 28(1): 15-23.
[54] Díez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003; 148(3): 293-300.
[55] Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7(8): 941-6.
Pathobiology Reserach
Volume 20, Issue 3
October 2017
Pages 17-32