The Role of Medicinal Plants in Treating Mild Cognitive Impairment: A Focus on Mitophagy Modulation

Document Type : Systematic Review

Authors
1 Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2 Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3 Occupational safety and health research center, NICICO, WSO and Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract
Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia, characterized by cognitive decline that is more pronounced than expected for age. While the exact mechanisms underlying MCI remain elusive, mounting evidence suggests that impaired mitophagy, a cellular process responsible for removing damaged mitochondria, may contribute to its development. Medicinal plants, rich in bioactive compounds, have shown promise in treating MCI. This review explores the potential of medicinal plants to ameliorate MCI by modulating mitophagy. We delve into the intricate interplay between mitophagy dysfunction and MCI, highlighting the pathways involved. Furthermore, we examine the reported effects of various medicinal plants on mitophagy, emphasizing their potential to restore mitochondrial homeostasis and protect cognitive function. Finally, we discuss future research directions and perspectives on the therapeutic potential of medicinal plants in MCI management.

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Subjects


[1] Sachdev PS, Blacker D, Blazer DG, Ganguli M, Jeste DV, Paulsen JS, et al. Classifying neurocognitive disorders: the DSM-5 approach. Nature reviews Neurology. 2014 Nov;10(11):634-42.
[2] Petersen RC, Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, et al. Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology. 2010 Sep 7;75(10):889-97.
[3] Sanford AM. Mild cognitive impairment. Clinics in geriatric medicine. 2017;33(3):325-37.
[4] Pehrson AL, Sanchez C. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS Spectr. 2014 Apr;19(2):121-33.
[5] Li X, Huang L, Lan J, Feng X, Li P, Wu L, et al. Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases. Pharmacological Research. 2021;163:105240.
[6] Hakimizadeh E, Kaeidi A, Hassanshahi J, Shamsizadeh A, Allahtavakoli M, Rahmani MR, et al. Amelioration of cisplatin-induced liver toxicity through antioxidative properties of hydroalcoholic extract of pistachio nuts in mice. 2019.
[7] Zamani M, Hassanshahi J, Soleimani M, Zamani F. Neuroprotective effect of olive oil in the hippocampus CA1 neurons following ischemia: Reperfusion in mice. Journal of neurosciences in rural practice. 2019 Apr;04(02):164-70.
[8] Mozafari N, Hassanshahi J, Ostadebrahimi H, Shamsizadeh A, Ayoobi F, Hakimizadeh E, et al. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. 2022;82(2):179-86.
[9] Zhou Y, Luo D, Shi J, Yang X, Xu W, Gao W, et al. Loganin alleviated cognitive impairment in 3× Tg-AD mice through promoting mitophagy mediated by optineurin. Journal of Ethnopharmacology. 2023;312:116455.
[10] Jiang Y, Li H, Huang P, Li S, Li B, Huo L, et al. Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy. Journal of Ethnopharmacology. 2022;285:114859.
[11] Li H-M, Jiang Y-X, Huang P-L, Li B-C, Pan Z-Y, Li Y-Q, et al. Ginsenoside Rg_1 protects PC12 cells against Aβ-induced injury through promotion of mitophagy by PINK1/parkin activation. Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica. 2022;47(2):484-91.
[12] Gao Y, Li J, Li J, Hu C, Zhang L, Yan J, et al. Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway. Biochemical pharmacology. 2020;177:113997.
[13] Chen Z, Yang Y, Han Y, Wang X. Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia. Frontiers in Pharmacology. 2022;13:937333.
[14] Tian Y, Qi Y, Cai H, Xu M, Zhang Y. Senegenin alleviates Aβ1-42 induced cell damage through triggering mitophagy. Journal of Ethnopharmacology. 2022;295:115409.
[15] Han Y, Wang N, Kang J, Fang Y. β-Asarone improves learning and memory in Aβ 1-42-induced Alzheimer’s disease rats by regulating PINK1-Parkin-mediated mitophagy. Metabolic brain disease. 2020;35:1109-17.
[16] Yang T, Zhao X, Zhang Y, Xie J, Zhou A. 6‴-Feruloylspinosin alleviated beta-amyloid induced toxicity by promoting mitophagy in Caenorhabditis elegans (GMC101) and PC12 cells. Science of the total environment. 2020;715:136953.
[17] Wang H, Jiang T, Li W, Gao N, Zhang T. Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease. Toxicology letters. 2018;282:100-08.
[18] Liu X, Lu J, Liu S, Huang D, Chen M, Xiong G, et al. Huangqi-Danshen decoction alleviates diabetic nephropathy in db/db mice by inhibiting PINK1/Parkin-mediated mitophagy. American Journal of Translational Research. 2020;12(3):989.
[19] Wen D, Tan R-Z, Zhao C-Y, Li J-C, Zhong X, Diao H, et al. Astragalus mongholicus Bunge and Panax notoginseng (Burkill) FH chen formula for renal injury in diabetic Nephropathy—In Vivo and In Vitro evidence for autophagy regulation. Frontiers in Pharmacology. 2020;11:732.
[20] Tohda C, Tamura T, Matsuyama S, Komatsu K. Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. British journal of pharmacology. 2006;149(5):532-41.
[21] Wang W-W, Liu X-L, Ding Y, Chen Y-D, Ma D, Bu R, et al. Scutellarin Protects Myocardial Ischemia-Reperfusion Injury ERK1/2-CREB Regulated Mitophagy. Pharmacognosy Magazine. 2023;19(4):1021-36.
[22] Shin J-W, Kweon K-J, Kim D-K, Kim P, Jeon T-D, Maeng S, et al. Scutellarin ameliorates learning and memory deficit via suppressing β-amyloid formation and microglial activation in rats with chronic cerebral hypoperfusion. The American Journal of Chinese Medicine. 2018;46(06):1203-23.
[23] Zeng Y-Q, Cui Y-B, Gu J-H, Liang C, Zhou X-F. Scutellarin mitigates Aβ-induced neurotoxicity and improves behavior impairments in AD mice. Molecules. 2018;23(4):869.
[24] Abudureyimu M, Yu W, Cao RY, Zhang Y, Liu H, Zheng H. Berberine promotes cardiac function by upregulating PINK1/Parkin-mediated mitophagy in heart failure. Frontiers in physiology. 2020;11:565751.
[25] de Oliveira JS, Abdalla FH, Dornelles GL, Adefegha SA, Palma TV, Signor C, et al. Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: involvement of acetylcholinesterase and cell death. Neurotoxicology. 2016;57:241-50.
[26] Qiang J, Yang R, Li X, Xu X, Zhou M, Ji X, et al. Monotropein induces autophagy through activation of the NRF2/PINK axis, thereby alleviating sepsis-induced colonic injury. International Immunopharmacology. 2024;127:111432.
[27] Zhang Y, Zhang M. Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer’s disease. Frontiers in Aging Neuroscience. 2022;14:963041.
[28] Liu C, Zhang M, Ye S, Hong C, Chen J, Lu R, et al. Acacetin Protects Myocardial Cells against Hypoxia‐Reoxygenation Injury through Activation of Autophagy. Journal of Immunology Research. 2021;2021(1):9979843.
[29] Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, et al. Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. Scientific Reports. 2017 Apr 11;7(1):46208.
[30] Xu B, Huang M, Qi H, Xu H, Cai L. Tomatidine activates autophagy to improve lung injury and inflammation in sepsis by inhibiting NF-κB and MAPK pathways. Molecular Genetics and Genomics. 2024;299(1):1-10.
[31] Yang L, Tao Y, Luo L, Zhang Y, Wang X, Meng X. Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis. Journal of Ethnopharmacology. 2022;288:114988.
[32] Jin Z, Chang B, Wei Y, Yang Y, Zhang H, Liu J, et al. Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy. Biomedicine & Pharmacotherapy. 2022 Jul;151:113092.
[33] Hong Y, Choi Y-H, Han Y-E, Oh S-J, Lee A, Lee B, et al. Central Administration of Ampelopsin A Isolated from Vitis vinifera Ameliorates Cognitive and Memory Function in a Scopolamine-Induced Dementia Model. Antioxidants. 2021 May 24;10(6):835.
[34] Parate SS, Upadhyay SS, S A, Karthikkeyan G, Pervaje R, Abhinand CS, et al. Comparative Metabolomics and Network Pharmacology Analysis Reveal Shared Neuroprotective Mechanisms of Bacopa monnieri (L.) Wettst and Centella asiatica (L.) Urb. 2024 May 30.