Dose-dependent U-shaped effect of losartan on seizure induced by pentylenetetrazol in rats

Document Type : Original Research

Authors
م. پالیزوان
M. Mousavi-Hasanzadeh
Arak University of Medical Sciences
Abstract
Introduction: Some experimental data show that losartan can exert anticonvulsant activity; thereby it could create the potential therapy for treatment of epilepsy. However, there are limited and confusing data regarding the anticonvulsant action of losartan. The aim of this study was to answer the question why different studies found different effects of losartan on seizure and epilepsy.

Methods: The Sub convulsive doses (37.5 mg/kg) of pentylenetetrazol (PTZ) were administered (at intervals of one another day), to induce chemical kindling in conscious, free-moving rats. Separate groups of full kindled rats were pretreated with 12.5, 25, 50, 100 and 200 mg/kg doses of losartan.

Results: The results showed although losartan had no significant effect on seizure stage, this drug induced a dose-dependent U-shaped effect on other seizure parameters.

Conclusion: These results may explain the discrepancy reported about the effect of losartan on kindling model of epilepsy.

Keywords

Subjects

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Pathobiology Reserach
Volume 26, Issue 1
November 2023
Pages 13-18