Aerobic Exercise Improves Cardiac Biomarkers in an Obese Rat Model Induced by High-Fat and Fructose Diet Via Nuclear Factor Erythroid 2/ Protein P21/Oxidation Resistance Protein Pathway

Document Type : Original Research

Authors
B. Salehi Mohsen 1
M. shariati 1
M. Radan 2
1 Department of Physical Education & Sport Sciences, Islamic Azad University, Ahvaz Branch. Ahvaz, Iran.
2 Persian Gulf Research Center, Medical Collage, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Abstract
Background: Obesity is considered as a major risk factor for chronic diseases such as cardiovascular dysfunction. The aim of the present study was to investigate the effect of aerobic training on the Nuclear Factor Erythroid 2 (NRF2)/ Protein P21 (P21)/Oxidation Resistance Protein (OXR1) pathway in the experimental model of obesity induced by high-fat and fructose diet.

Materials and methods: Twenty-Four male Wistar rats were randomly divided into three groups including standard diet, high-fat/fructose diet and high-fat/fructose diet+ Aerobic exercise group. At the end of study, the anthropometrics parameters, lipid profile and antioxidant gene expression (OXR1, P21, NRF2) were measured in all groups.

Results: A high-fat diet containing fructose increased serum total cholesterol, body mass index, and Li index in male rats. The expression level of OXR1, Nrf2 and P21 genes in the cardiac tissue of obese rats was changes compare to the control group. However, 8 weeks exercise caused to improves the cardiac damage parameters and antioxidant genes in obese rats.

Conclusion: It seems that aerobic exercise could modulate the antioxidant defense system and improve fat metabolism in cardiac tissue. It is suggested that aerobic exercise can be considered as useful treatment in obese patients with cardiovascular dysfunction.

Keywords

Subjects

there are many definitions and classifications for obesity, the most important acceptable classification of the World Health Organization for defining obesity is based on body mass index
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Pathobiology Reserach
Volume 27, Issue 2
November 2024
Pages 13-22