Effect of Resistance Training on Soleus Muscle Mass and Gene Expression of AMPK and PI3K in Rats with Type 2 Diabetes

Document Type : Original Research

Authors
M. Eizadi 1
H. eslami 2
M. Rozbayani 2
1 Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran.
2 Department of Exercise physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
Abstract
Introduction: Clinical studies have pointed to muscle atrophy in diabetic patients. This study was conducted with the aim of determining the effect of resistance training on the expression of some transcription factors effective on muscle hypertrophy in type 2 diabetic rats.

Methods: For this purpose, type 2 diabetes was induced by intraperitoneal injection of nicotinamide-STZ in fourteen male Wistar rats (220 ± 10 g). Then diabetic rats were randomly selected in resistance and control groups. Rats in the resistance group participated in a 10-week resistance training (5 times weekly) in the form of climbing a step ladder with resistance (tying a weight to the tail based on the percentage of body weight), and the control group did not participate in the exercises. 48 hours after the last training session, the expression of PI3K and AMPK genes in the soleus muscle, as well as the weight of the soleus muscle and the ratio of soleus muscle weight to body weight (soleus/body weight ratio) were measured and compared by independent t test between groups.

Results: Compared to control group, resistance training resulted in significant increase in PI3K expression, soleus muscle weight and soleus/body weight ratio (P < 0.05).

Conclusion: Resistance training leads to soleus muscle hypertrophy in diabetic rats, and this improvement can probably be attributed to the increased PI3K expression.

Keywords

Subjects

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Pathobiology Reserach
Volume 27, Issue 3
November 2024
Pages 63-69