Brief review of deep brain stimulation anticonvulsant mechanisms in epilepsy

Document Type : Systematic Review

Authors
P. Jadidi 1
M. Mohammadi 2
1 Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2 Department of Biophysics, Institute of Biophysics and Biochemistry, University of Tehran, Tehran, Iran
Abstract
Deep Brain Stimulation (DBS) has been developed as a new therapeutic manner for the treatment of neurological disorders, offering a reversible and adjustable alternative to traditional lesion-based surgeries. By delivering targeted electrical stimulation to specific brain regions, DBS modulates neural circuits and restores dysfunctional networks. Beyond its established role in movement disorders like Parkinson’s disease, DBS has shown remarkable efficacy in managing epilepsy. Its therapeutic effects are mediated through complex mechanisms, including neurotransmitter modulation, ion channel regulation, and alterations in the brain’s microenvironment. This article explores how DBS leverages these multifaceted processes to revolutionize neuromodulation and offers insights into its expanding potential for treating epilepsy.

Keywords: Deep Brain Stimulation, Epilepsy, Anticonvulsant, Seizure

Keywords

Subjects

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Pathobiology Reserach
Volume 27, Issue 4
December 2024
Pages 39-43