The effect of testosterone consumption during resistance training on the expression of some genes related to heart damage of male Wistar rats

Document Type : Original Research

Authors
R. Ghanei 1
A. A. Banaeifar 2
A. Gorzi 3
S. Arshadi 1
1 Department of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran
2 Department of Physical Education and Sports Sciences, Islamic Azad University, South Tehran branch, Tehran, Iran
3 Department of Sport Sciences, University of Zanjan, Zanjan, Iran
Abstract
Introduction: Many studies have addressed the side effects of anabolic steroid abuse in different tissues such as heart tissue. The purpose of this research is to study the effect of 8 weeks of resistance training and testosterone consumption on some indicators of heart tissue damage in male rats.

Methods: 21 adult male Wistar rats aged 8 weeks (220 ± 10 g) were randomly divided into 3 groups: control, training (resistance training) and training + testosterone groups. The intervention of resistance exercise and testosterone injection lasted for 8 weeks. Resistance exercises were performed 5 times a week in the form of climbing a step ladder with resistance applied by tying a weight to the tail (4 sets, 6 repetitions in each set). Testosterone enanthate was injected intramuscularly 3 days a week (20 mg/kg). One-way ANOVA and Tukey's post hoc test were used to compare variables.

Results: Creatine kinase-MB (CK-MB) expression increased significantly in the training + testosterone compared to the control group (P<0.05). No significant difference was observed in troponin expression between the studied groups (P>0.05).

Conclusion: It seems that testosterone enanthate administration during resistance training leads to cardiac tissue damage in laboratory rats.

Keywords

Subjects

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Pathobiology Reserach
Volume 27, Issue 4
December 2024
Pages 45-52