The effect of six weeks aerobic training on sPLA2 and COX-2 genes expression In Balb/c mice with breast cancer

Introduction: Clinical evidence points to the development of breast cancer in women as being rooted in genetic and hormonal factors. The present study aimed to determine the effect of aerobic training on the expression of some transcription factors (sPLA2, COX-2) in breast tissue that are effective in breast cancer tumor growth in Balb/c mice.
Methods: For this purpose, breast cancer was induced by 4T1 tumor cells in 14 Balb/c mice (Animal house, Pasteur Institute, Iran), then were randomly divided into exercise (aerobic training, n = 7) or control (n = 7) groups. Aerobic training was performed 5 sessions weekly in the form of running on a rodent treadmill for 6 weeks. sPLA2, COX-2 genes expression in Breast tumor tissue were measured at 48 hours after lasting exercise in 2 groups. Independent t-test (SPSS. 22) was used for comparing variables between groups.
Results: Compared to the control group, aerobic training induced significant decrease in sPLA2 (p = 0.001) and COX-2 (p = 0.001) expression in Breast tumor tissue.
Conclusion: These findings supports the effectiveness of aerobic training as a non-pharmacological treatment to inhibit the growth or severity of breast cancer. Further studies are required to understand the main mechanisms responsible for the exercise training on the factors affecting the growth and progression of breast cancer.