The effect of O10plus supplementation during total resistance exercises on serum nitric oxide and H2O2 as vascular endothelial function in inactive overweight females

Document Type : Original Article

Authors
Mojtaba Eizadi 1
Fatemeh Mohammadi 1
Hamidreza Samarikhalaj 2
Mohammad Rashidi 3
1 Department of Exercise physiology, Sa.C., Islamic Azad University, Saveh, Iran
2 Department of Physical Education and Sport Sciences, Sa.C., Islamic Azad University, Saveh, Iran
3 Department of Exercise physiology, Se.C., Islamic Azad University, Semnan, Iran
10.48311/mjms.2026.119076.82617
Abstract
Introduction: Obesity and overweight is associated with metabolic disorders such as type 2 diabetes and vascular endothelial dysfunction. This study aimed to assess the effect of Q10plus ingestion during total resistance exercises (TRX) training on nitric oxide (NO) and hydrogen peroxide (H2O2) as vascular endothelial function in inactive overweight females.
Methods: In this semi-experimental study, 48 adult overweight females aged 30-40 years were randomly divided into control (no intervention); exercise (TRX training, 8 weeks), supplement (Q10plus, 8 weeks, 100 mg/daily) and combined group (TRX+ Q10plus). Anthropometrical indices and fasting serum NO and H2O2 concentration were measured before and 48 after lasting exercise session and compared by ANCOVA with Bonferroni post hoc test between groups.
Results: Serum NO significantly increased in exercise (p=0.001), supplement (p=0.026) and combination (p=0.001) groups. In addition, H2O2 significantly decreased by exercise and combination groups compared to control group (p=0.028, p=0.019 respectively). No significant difference were observed between other groups (p > 0.05).
Conclusion: Based on these findings, although TRX and Q10Plus consumption are each independently associated with improved vascular endothelial function, their simultaneous implementation is not more effective than either of them alone.
Keywords
Q10plus
TRX training
Vascular function
Overweight
Nitric Oxide
Subjects