Volume 21, Issue 3 (2018)                   mjms 2018, 21(3): 163-171 | Back to browse issues page

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1- Tissue Engineering Department, Advanced Technologies Faculty, Shahrekord University of Medical Sciences, Shahrekord, Iran
2- Fertility & Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Fertility & Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran , mkhkhazaei@gmail.com
Abstract:   (7918 Views)
Introduction: Cancer is abnormal cell proliferation and uncontrolled cell growth. Carcinogenic agents cause DNA injury, depletion of tumor suppressor gene functions and it cause tumor forming and metastasis. Some carcinogenic agents related to cancer etiology are physical carcinogens such as ultra violet, chemical carcinogens such as chemical materials, cigarette smoke, unbalanced diet, job dependent factors, inheritance, hormones, metabolic factors and biologic agents especially some bacteria and viruses. Today’s most important treatment for cancer is chemotherapy that has many side effects and additionally cause to drug resistance. Some plants for years are known as reliable and excellent source of anticancer agents to develop anticancer drugs. Some of plants have preventive and therapeutic effects on cancer and some of them can decrease side effects of chemotherapy and radiotherapy and additionally are economic. This article reviewed the most important anticancer natural substances in the world and introduced the most important mechanisms of their effect.
Conclusion: In traditional medicine of the most countries have known many natural substances for a variety of cancers. Some of the most commonly known traditional anticancer materials in the world are Chinese rabdosia, polyphenolic flavonoids such as quercetin, Baicalensis Scutellaria, garlic, curcumin, and so on. Anticancer drug mechanisms of the most of these substances are related to antioxidant properties and inhibit the growth of their tumor cells. Many of these materials are traditionally used in different parts of the world.
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Article Type: Review | Subject: Biochemistry
Received: 2017/10/29 | Accepted: 2018/01/16

1. Joyce Nirmala M, Samundeeswari A, Deepa Sankar P. Natural plant resources in anti-cancer therapy-a review. Res Plant Biol. 2011;1(3):1-14. [Link]
2. Agarwal N, Majee C, Chakraborthy GS. Natural herbs as anticancer drugs. Int J PharmTech Res. 2012;4(3):1142-53. [Link]
3. Zhou H, Zou P, Chen ZC, You Y. A novel vicious cycle cascade in tumor chemotherapy. Med Hypotheses. 2007;69(6):1230-3. [Link] [DOI:10.1016/j.mehy.2007.03.038]
4. Kafash Farkhad N, Asadi Samani M, Khaledifar B. A review on secondary metabolites and pharmacological effects of Prangos ferulacea (L.) Lindl. J Shahrekord Univ Med Sci. 2013;15(3):98-108. [Persian] [Link]
5. Ghaemi A, Soleimanjahi H, Razeghi S, Gorji A, Tabaraei A, Moradi A, et al. Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer. Iran J Immunol. 2012;9(2):119-27. [Link]
6. Jahromi SR, Arrefhosseini SR, Ghaemi A, Alizadeh A, Sabetghadam F, Togha M. Effect of oral genistein administration in early and late phases of allergic encephalomyelitis. Iran J Basic Med Sci. 2014;17(7):509-15. [Link]
7. Razeghi Jahromi S, Arrefhosseini SR, Ghaemi A, Alizadeh A, Moradi Tabriz H, Togha M. Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein. Iran J Allergy Asthma Immunol. 2014;13(4):256-64. [Link]
8. Yin B, Sheng H, Lin J, Zhou H, Zhang N. The cell death of C6 astrocytoma cells induced by oridonin and its mechanism. Int J Clin Exp Pathol. 2012;5(6):562-8. [Link]
9. Ikezoe T, Yang Y, Bandobashi K, Saito T, Takemoto S, Machida H, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther. 2005;4(4):578-86. [Link] [DOI:10.1158/1535-7163.MCT-04-0277]
10. Singh Baghel S, Shrivastava N, Singh Baghel R, Agrawal P, Rajput S. A review of quercetin: Antioxidant and anticancer properties. World J Pharm Pharm Sci. 2012;1(1):146-60. [Link]
11. Naidu PVS, Kinthada PMMS, Kalyani P, Muralidhar P. Characterization and biological activities of quercetin thiosemicarbazone derivatives: potential anti cancer drugs. Int J Pharm Biomed Sci. 2012;3(2):24-7. [Link]
12. Xing N, Chen Y, Mitchell SH, Young CY. Quercetin inhibits the expression and function of androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001;22(3):409-14. [Link] [DOI:10.1093/carcin/22.3.409]
13. Peng Y, Sun M, Di Y, Huo X, Fu Z, Li Q, et al. Antitumor effect of the ethanol extract of Scutellaria baicalensis on the mice bearing U14 cervical cancer. Afr J Biotechnol. 2012;11(24):6542-9. [Link] [DOI:10.5897/AJB11.3485]
14. Scheck AC, Perry K, Hank NC, Clark WD. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. BMC Complement Altern Med. 2006;6:27. [Link] [DOI:10.1186/1472-6882-6-27]
15. Li-Weber M. New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009;35(1):57-68. [Link] [DOI:10.1016/j.ctrv.2008.09.005]
16. Agarwal R, Agarwal C, Ichikawa H, Singh RP, Aggarwal BB. Anticancer potential of silymarin: from bench to bed side. Anticancer res. 2006;26(6B):4457-98. [Link]
17. Singh RP, Agarwal R. A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer. Mutat Res. 2004;555(1-2):21-32. [Link] [DOI:10.1016/j.mrfmmm.2004.05.017]
18. Ranjani R, Ayya-Raju M. Anticancer properties of Allium sativum–a review. Asian J Biochem Pharm Res. 2012;2(3):190-6. [Link]
19. Entezari M, Majd A, Falahian F, Mehrabian S, et al. Antimutagenicity and anticancer effects of citrus medica fruit juice. Acta Med Iran. 2009;47(5):373-7. [Link]
20. Panditrao Palve Y, Nayak PL. Curcumin: A wonder anticancer drug. Int J Pharm Biomed Sci. 2012;3(2):60-9. [Link]
21. Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55(2):126-31. [Link] [DOI:10.1207/s15327914nc5502_2]
22. Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008;269(2):199-225. [Link] [DOI:10.1016/j.canlet.2008.03.009]
23. Mitra A, Chakrabarti J, Banerji A, Chatterjee A, Das BR. Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ Pathol Toxicol Oncol. 2006;25(4):679-90. [Link] [DOI:10.1615/JEnvironPatholToxicolOncol.v25.i4.70]
24. Bhandarkar SS, Arbiser JL. Curcumin as an inhibitor of angiogenesis. Adv Exp Med Biol. 2007;595:185-95. [Link] [DOI:10.1007/978-0-387-46401-5_7]
25. Arbiser JL, Klauber N, Rohan R, Van Leeuwen R, Huang MT, Fisher C, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 1998;4(6):376-83. [Link] [DOI:10.1007/BF03401744]
26. Hemati S, Saeedi A. Clinical evaluation of oral curcumin in prevention of acute dermatitis in breast cancer radiotherapy. J Isfahan Med Sch. 2011;29(152):1216-23. [Persian] [Link]
27. Katiraee F, Babaei E, Ghaderi A, Ashrafi Helan J. Effect of dendrosomal nanocurcumin on CaMCA1 gene expression and encoding metacaspase in candida species and its possible role in cell death. J Isfahan Med Sch. 2016;34(394):933-9. [Persian] [Link]
28. Rhimi H, Foroumadi A, Shokrgozar MA, Mahdian R, Madadkar Sobhan A, Karimipoor M. Inhibitory effects of curcumin and 2-methoxyestradiaul on anaphase promoting complex in hela cancer cells. J Isfahan Med Sch. 2013;31(228):255-64. [Link]
29. Randhawa MA, Al Ghamdi MS. A review of the pharmaco-therapeutic effects of Nigella sativa. Pakistan J Med Res. 2002;41(2):77-83. [Link]
30. Swamy SM, Tan BK. Cytotoxic and immunopotenciating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol. 2000;70(1):1-7. [Link] [DOI:10.1016/S0378-8741(98)00241-4]
31. Bozorgi A, Khazaei M, Khazaei MR. New findings on breast cancer stem cells: A review. J Breast Cancer. 2015;18(4):303-12. [Link] [DOI:10.4048/jbc.2015.18.4.303]
32. Farah IO, Begum RA. Effect of Nigella sativa (N. sativa L.) and oxidative stress on survival pattern of MCF-7 breast cancer cells. Biomed Sci Instrum. 2003;39:359-64. [Link]
33. Islam SN, Begum P, Ahsan T, Huque S, Ahsan M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother Res. 2004;18(5):395-8. [Link] [DOI:10.1002/ptr.1449]
34. Ait Mbarek L, Ait Mouse H, Elabbadi N, Bensalah M, Gamouh A, Aboufatima R, et al. Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Braz J Med Biol Res. 2007;40(6):839-47. [Link] [DOI:10.1590/S0100-879X2006005000108]
35. Gali-Muhtasib H, Diab-Assaf M, Boltz C, Al-Hmaira J, Roessner A, et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol. 2004;25(4):857-66. [Link]
36. Bishayee A. Cancer prevention and treatment with resveratrol: From rodent studies to clinical trials. Cancer Prev Res (Phila). 2009;2(5):409-18. [Link] [DOI:10.1158/1940-6207.CAPR-08-0160]
37. Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA. Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis. 2007;28(9):1946-53. [Link] [DOI:10.1093/carcin/bgm144]
38. Seeni A, Takahashi S, Takeshita K, Tang M, Sugiura S, Sato SY, et al. Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev. 2008;9(1):7-14. [Link]
39. Tessitore L, Davit A, Sarotto I, Caderni G. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis. 2000;21(8):1619-22. https://doi.org/10.1093/carcin/21.8.1619 [Link] [DOI:10.1093/carcin/21.5.619]
40. Sengottuvelan M, Viswanathan P, Nalini N. Chemopreventive effect of trans-resveratrol--a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis. Carcinogenesis. 2006;27(5):1038-46. [Link] [DOI:10.1093/carcin/bgi286]
41. Kimura Y, Okuda H. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J Nutr. 2001;131(6):1844-9. [Link] [DOI:10.1093/jn/131.6.1844]
42. Van Ginkel PR, Sareen D, Subramanian L, Walker Q, Darjatmoko SR, Lindstrom MJ, et al. Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria. Clin Cancer Res. 2007;13(17):5162-9. [Link] [DOI:10.1158/1078-0432.CCR-07-0347]
43. Kakeh Baraei S, Niroumand E, khazaei M. Biopharmacologic Properties of Resveratrol. J Isfahan Med Sch. 2015;32(308):1879-96. [Persian] [Link]
44. Medina-Holguín AL, Omar Holguín F, Micheletto S, Goehle S, Simon JA, O'Connella MA. Chemotypic variation of essential oils in the medicinal plant Anemopsis californica. Phytochemistry. 2008;69(4):919-27. [Link] [DOI:10.1016/j.phytochem.2007.11.006]
45. Harlev E, Nevo, E, Lansky EP, Lansky S, Bishayee A. Anticancer attributes of desert plants: A review. Anticancer Drugs. 2012;23(3):255-71. [Link] [DOI:10.1097/CAD.0b013e32834f968c]
46. Kandouz M, Alachkar, A, Zhang L, Dekhil H, Chehna F, Yasmeen A, et al. Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex. J Ethnopharmacol. 2010;129(3):410-5. [Link] [DOI:10.1016/j.jep.2009.10.035]
47. Conforti F, Statti, G, Tundis R, Loizzo MR, Bonesi M, Menichini F, et al. Antioxidant and cytotoxic activities of Retama raetam subsp; Gussonei. Phytother Res. 2004;18(7):585-7. [Link] [DOI:10.1002/ptr.1496]
48. Berrougui H, Lopez-Lazaro M, Martin-Cordero C, Mamouchi M, Ettaib A, Herrera MD. Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L. J Nat Rem. 2005;5(1):41-5. [Link]
49. Nishino H, Murakosh M, Ii T, Takemura M, Kuchide M, Kanazawa M, et al. Carotenoids in cancer chemoprevention. Cancer Metastasis Rev. 2002;21(3-4):257-64. [Link] [DOI:10.1023/A:1021206826750]
50. Gill CI, Boyd A, McDermott E, McCann M, Servili M, Selvaggini R, et al. Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro. Int J Cancer. 2005;117(1):1-7. [Link] [DOI:10.1002/ijc.21083]
51. Llor X, Pons E, Roca A, Alvarez M, Ma-é J, Fernández-Ba-ares F, et al. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clin Nutr. 2003;22(1):71-9. [Link] [DOI:10.1054/clnu.2002.0627]
52. Luk SU, Yap WN, Chiu YT, Lee DT, Ma S, Lee TK, et al. Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. Int J Cancer. 2011;128(9):2182-91. [Link] [DOI:10.1002/ijc.25546]
53. Yano Y, Satoh, H, Fukumoto K, Kumadaki I, Ichikawa T, Yamada K, et al. Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol. Int J Cancer. 2005;115(5):839-46. [Link] [DOI:10.1002/ijc.20809]
54. Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, et al. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): A short review. Phytother Res. 2007;21(6):501-6. [Link] [DOI:10.1002/ptr.2124]
55. Messina MJ. Soyfoods: Their role in disease prevention and treatment. In: Liu K. Soybean: Chemistry, technology, and utilization. London: Chapman and Hall; 1997. pp. 442-77. [Link] [DOI:10.1007/978-1-4615-1763-4_10]
56. Yi MA, Son HM, Lee JS, Kwon CS, Lim JK, Yeo YK. Soybean constituents and functional benefits. Nutr Cancer. 2002;42:206-10. [Link] [DOI:10.1207/S15327914NC422_9]
57. MacDonald RS, Guo J, Copeland J, Browning JD Jr, Sleper D, Rottinghaus GE, et al. Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer. J Nutr. 2005;135(5):1239-42. [Link] [DOI:10.1093/jn/135.5.1239]
58. Jun HS, Kim SE, Sung MK. Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation. J Med food. 2002;5(4):235-40. [Link] [DOI:10.1089/109662002763003393]
59. Mohamad RH, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, et al. Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare). J Med Food. 2011;14(9):986-1001. [Link] [DOI:10.1089/jmf.2008.0255]
60. Brozmanová J, Mániková D, Vlčková V, Chovanec M. Selenium: A double-edged sword for defense and offence in cancer. Arch Toxicol. 2010;84(12):919-38. [Link] [DOI:10.1007/s00204-010-0595-8]
61. Guan L, Huang F, Li Z, Han B, Jiang Q, Ren Y, et al. P53 transcription-independent activity mediates selenite-induced acute promyelocytic leukemia NB4 cell apoptosis. BMB Rep. 2008;41(10):745-50. [Link] [DOI:10.5483/BMBRep.2008.41.10.745]
62. Sarveswaran S, Liroff J, Zhou Z, Nikitin AY, Ghosh J. Selenite triggers rapid transcriptional activation of p53, and p53-mediated apoptosis in prostate cancer cells: Implication for the treatment of early-stage prostate cancer. Int J Oncol. 2010;36(6):1419-28. [Link]
63. Abedi J, Tukmechi A, Nejati V, Hobbenaghi R. Preventive impacts of selenium-enriched yeast on liver and enzyme activity after inducing colorectal cancer in rat. J Isfahan Med Sch. 2014;32(291):991-1003. [Link]
64. Rezakhani L, Rashidi Z, Mirzapur P, Khazaei M. Antiprolieratory effect of crab shell extract on breast cancer cell line(MCF7). J Breast Cancer. 2014;17(3):219-25. [Link] [DOI:10.4048/jbc.2014.17.3.219]
65. Mirzapur P, Rashidi Z, Rezakhani L, Khazaei M. In vitro inhibitory effect of crab shell extract on human umbilical vein endothelial cell. In Vitro Cell Dev Biol Anim. 2015;51(1):36-41. [Link] [DOI:10.1007/s11626-014-9810-x]
66. Rezakhani L, Khazaei MR, Ghanbari A, Khazaei M. Crab shell extract induced prostate cancer cell line (LNcap) apoptosis and decreased nitric oxide secretion. Cell J. 2017;19(2):231-7. [Link]

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