Volume 21, Issue 3 (2018)                   mjms 2018, 21(3): 125-131 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vizvari E, Farzanegi P, Abbas Zade Sourati H. Effect of Vigorous Aerobic Training on Serum Levels of Some Inhibitory and Excitatory Factors of Angiogenesis in Women with Type 2 Diabetes. mjms. 2018; 21 (3) :125-131
URL: http://mjms.modares.ac.ir/article-30-16360-en.html
1- Exercise Physiology Department, Humanities Faculty, Sari Branch, Islamic Azad University, Sari, Iran
2- Exercise Physiology Department, Humanities Faculty, Sari Branch, Islamic Azad University, Sari, Iran , parvinfarzanegi@yahoo.com
Abstract:   (7776 Views)
Aims: Vascular disorder is one of the consequences of diabetes. Physical activity also plays an important role in the improvement of this disorder. Therefore, the aim of this study was to investigate the effect of vigorous aerobic training on serum levels of inhibitory and excitatory factors of Angiogenesis in women with type 2 diabetes.
Materials and Methods: In this quasi-experimental study with pre-test and post-test design that was performed among women with diabetes population in Gorgan in volunteer sampling, 28 women with type 2 diabetes in Gorgan were selected By … sampling method and were divided into training and control groups (14 individuals each group). Training intervention consisted 8 weeks of vigorous aerobic exercise (70%-80%) with 3 times per week. Just before the exercise and 48 hours after that, serum levels of Nitric Oxide (NO), Vascular Endothelial Growth Factor (VEGF), and Endostatin (ES) were evaluated. The data were analyzed by SPSS24 software, using repeated measures ANOVA..
Findings: Eight weeks of aerobic training caused a significant increase in serum levels of NO (p=0.016), VEGF (p=0.036), and an insignificant increase in ES (p=0.237). Also, a significant decrease was observed in fasting blood glucose (p=0.027) and A1C (p=0.003) compared to the control group.
Conclusion: Regular aerobic exercise improves serum levels of angiogenesis-related and metabolic factors in women with type 2 diabetes.
Full-Text [PDF 430 kb]   (1231 Downloads)    
Article Type: Original Manuscipt | Subject: Biochemistry
Received: 2018/02/19 | Accepted: 2018/04/17

1. Farzanegi P. The effect of regular swim training with two different time periods on serum levels of NO, VEGF, and TGF-β1 in diabetic male rats. Pathobiol Res. 2017;20(2):37-48. [Persian] [Link]
2. FízeI'ová M, Cederberg H, Stančáková A, Jauhiainen R, Vangipurapu J, Kuusisto J, et al. Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease. PloS one. 2014;9(10):e109772. [Link] [DOI:10.1371/journal.pone.0109772]
3. Salehi E, Amjadi FS, Khazaei M. Angiogenesis in health and disease: Role of vascular endothelial growth factor (VEGF). J Isfahan Med Sch. 2011;29(132):312-26. [Persian] [Link]
4. Carmeliet P, Luttun A. The emerging role of the bone marrow-derived stem cells in (therapeutic) angiogenesis. Thromb Haemost. 2001;86(1):289-97. [Link]
5. Hadi H, Gaeini AA, Mo'tamedi P, Rajabi H. The effect of aerobic training on VEGF expression in diabetic rats. Med J Tabriz Uni Med Sciences Health Services. 2017;39(5):81-90. [Persian] [Link]
6. Salehi E, Khazaei M, Rashidi B, Haghjooye Javanmard Sh. Effect of rosiglitazone on coronary angiogenesis in diabetic and control rats. J Isfahan Med Sch. 2011;29(134):386-93. [Persian] [Link]
7. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res 2010;107(9):1058-70. [Link] [DOI:10.1161/CIRCRESAHA.110.223545]
8. Mehri Alvar Y, Sayevand Z, Erfani Adab. F, Heydari Moghadam R, Samavat Sharif MA, Karami S. The effects of five weeks' resistance training on some vascular growth factors in sedentary men. Sport Physiol. 2016;8(29):15-30. [Persian] [Link]
9. Jalali Z, Dabidi Roshan V. The Effect of Regular Endurance Exercises and Galbanum Supplement on Vascular Function during Chronic Hypertension in Male Wistar Rats. Sport Biosciences. 2014;6(1):95-113. [Persian] [Link]
10. Hamilton SJ, Watts GF. Endothelial dysfunction in diabetes: Pathogenesis, significance, and treatment. Rev Diabet Stud. 2013;10(2-3):133-56. [Link] [DOI:10.1900/RDS.2013.10.133]
11. Mahrou M, Gaeini AA, Chobbineh S, Javidi M. Changes in stimulating factors of angiogenesis, induced by progressive resistance training in diabetic rats. Iran J Diabetes Metab. 2014;14(1):1-8. [Persian] [Link]
12. Taheri Chadorneshin H, Ranjbar K, Nourshahi M. A Review of Response of Angiogenic and Angiostatic Factors to Exercise. Horizon Med Sci. 2017;23(4):331-8. [Persian] [Link]
13. Ferrari G, Cook BD, Terushkin V, Pintucci G, Mignatti P. Transforming growth factor-beta 1 (TGF-β1) induced angiogenesis through vascular endothelial growth factor (VEGF)-mediated apaptosis. J Cell Physiol. 2009;219(2):449-58. [Link] [DOI:10.1002/jcp.21706]
14. Tolouei Azar J, Ravasi AA, Soori R, Akbarnejad A, Hemati Nafar M. The effect of 8 weeks aerobic training on angiogenesis (VEGF) and angiostatic (ES) factors in sedentary women. J Urmia Univ Med Sci. 2017;27(12):1032-40. [Persian] [Link] [DOI:10.18869/acadpub.umj.27.12.1032]
15. Sodha NR, Clements RT, Boodhwani M, Xu SH, Laham RJ, Bianchi C, et al. Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Am J Physiol Heart Circ Physiol. 2009; 296(2):H428-34. [Link] [DOI:10.1152/ajpheart.00283.2008]
16. American Diabetes Association. Lifestyle management. Diabetes Care. 2017;40(Suppl 1):S33-43. [Link] [DOI:10.2337/dc17-S007]
17. Green DJ, Spence A, Halliwill JR, Cable NT, Thijssen DH. Exercise and vascular adaptation in asymptomatic humans. Exp physiol. 2011;96(2):57-70. [Link] [DOI:10.1113/expphysiol.2009.048694]
18. Maiorana A, O'Driscoll G, Cheetham C, Dembo L, Stanton K, Goodman C, et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol. 2001;38(3):860-6. [Link] [DOI:10.1016/S0735-1097(01)01439-5]
19. gharadashi Afousi AR, Gaeini AA, Gholami Borujeni B. The effect of aerobic interval training on endothelial vasculature function in type 2 diabetes patient. Iran J Rehabilit Res Nurs. 2016;2(3):27-39. [Persian] [Link]
20. Bashiri J, Gaeini AA, Hadi H. Endurance training affects muscular angiogenesis and serum VEGF concentration in diabetic rats. Koomesh. 2015;17(1):123-32. [Persian] [Link]
21. Rojas Vega S, Knicker A, Hollmann W, Bloch W, Strüder HK. Effect of resistance exercise on serum levels of growth factors in humans. Horm Metab Res. 2010;42(13):982-6. [Link] [DOI:10.1055/s-0030-1267950]
22. Brixius K, Schoenberger S, Ladage D, Knigge H, Falkowski G, Hellmich M, et al. Long-term endurance exercise decreases antiangiogenic endostatin signalling in overweight men aged 50-60 years. Br J Sports Med. 2008;42(2):126-9. [Link] [DOI:10.1136/bjsm.2007.035188]
23. Suhr F, Brixius K, De Marées M, Bölck B, Kleinöder H, Achtzehn S, et al. Effects of short-term vibration and hypoxia during high-intensity cycling exercise on circulating levels of angiogenic regulators in humans. J Appl Physiol. 2007;103:474-83. [Link] [DOI:10.1152/japplphysiol.01160.2006]
24. Takhshid MA, Ghasemi M. Methods for assessing insulin sensitivity and resistance. J Lab Diagn. 2014;6(23):8-13. [Persian] [Link]
25. Bazyar F, Banitalebi E, Amirhosseini SE. The comparison of two methods of exercise (intense interval training and concurrent resistance- endurance training) on fasting sugar, insulin and insulin resistance in women with mellitus diabetes. Armaghan-e-Danesh 2016;21(2):123-34. [Persian] [Link]
26. Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: Molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ 2014;38(4):308-14. [Persian] [Link] [DOI:10.1152/advan.00080.2014]
27. Shekarchizadeh P, Khazaei M, Gharakhanlou R, Karimian J, Safarzadeh AR. The effects of resistance training on plasma angiogenic factors in normal rats. J Isfahan Med Sch. 2012;30(176):1-9. [Persian] [Link]
28. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms. Circulation. 2006;113(15):1888-904. [Link] [DOI:10.1161/CIRCULATIONAHA.105.563213]
29. Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, et al. Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress. Diabetologia. 2010;53(5):989-1000. [Link] [DOI:10.1007/s00125-010-1677-0]
30. Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest. 1996;98(4):894-8. [Link] [DOI:10.1172/JCI118871]
31. Higashi Y, Yoshizumi M. Exercise and endothelial function: Role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacol Ther. 2004;102(1):87-96. [Link] [DOI:10.1016/j.pharmthera.2004.02.003]
32. Nourshahi M, Ghasemi Beyrami M, Babaei A, Hasan Z. Effect of Six weeks continuous aerobic training on tumoral tissue expression of vascular endothelial growth factor (VEGF) and Endostatin in Mice with Breast Cancer. Med J Tabriz Univ Med Sci Health Serv. 2013;34(6):82-9. [Persian] 36- Leick L, Hellsten Y, Fentz J, Lyngby SS, Wojtaszewski JF, Hidalgo J, et al. PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice. Am J Physiol Endocrinol Metab. 2009;297(1):E92-103. 37- Karami S, Ramezani AR. Adaptation in response of excitation and inhibition factors of angiogenesis after 4 weeks of progressive resistant training in sedentary men. Horizon Med Sci. 2016;22(4):267-74. [Persian] [Link]
33. Clark AN, Youkey R, Liu X, Jia L, Blatt R, Day YJ, et al. A1 adenosine Receptor activation promotes angiogenesis and release of VEGF from monocytes. Circ Res. 2007;101(1):1130-8. [Link] [DOI:10.1161/CIRCRESAHA.107.150110]
34. Poulaki V, Joussen AM, Mitsiades N, Mitsiades CS, Iliaki EF, Adamis AP. Insulin-like growth Factor-I plays a pathogenetic role in diabetic retinopathy. Am J Pathol. 2004;165(2):457-69. [Link] [DOI:10.1016/S0002-9440(10)63311-1]
35. Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle. J Appl Physiol. 2009;106(3):929-34. [Link] [DOI:10.1152/japplphysiol.90880.2008]
36. Wang H, Chen Y, Lu X, Liu G, Fu Y, Luo Y. Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis. Diabetes. 2015;64(7):2442-56. [Link] [DOI:10.2337/db14-0528]
37. Karami S, Ramezani AR. Adaptation in response of excitation and inhibition factors of angiogenesis after 4 weeks of progressive resistant training in sedentary men. Horizon Med Sci. 2016;22(4):267-74. [Persian] [Link] [DOI:10.18869/acadpub.hms.22.4.267]
38. Wang H, Chen Y, Lu X, Liu G, Fu Y, Luo Y. Endostatin prevents dietary-induced obesity by inhibiting adipogenesis and angiogenesis. Diabetes. 2015;64(7):2442-56. [Link] [DOI:10.2337/db14-0528]

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.