Volume 22, Issue 3 (2019)                   mjms 2019, 22(3): 141-147 | Back to browse issues page

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1- Hematology Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran , n.baheiraei@modares.ac.ir
2- Anatomical Sciences Department, Medical Sciences Faculty, Tarbiat Modares University, Tehran, Iran
Abstract:   (5770 Views)
Aims: Growing experiments show that biomaterials that have a bioactive glass (BG) indicate encouraging effects on bone tissue repair. Strontium-substituted BGs (BG/Sr) have been confirmed to improve bone formation while preventing bone resorption by osteoclasts.
Materials and Methods: This study aimed to evaluate the potential of strontium substitution on bioglass/gelatin (Gel) osteogenesis in critically sized rabbit calvarial defects. Defects were treated with Gel-BG or Gel-BG/Sr scaffolds and one defect was left unfilled as a control. Bone regeneration and mineralization process were evaluated by hematoxylin and eosin, Masson’s trichrome and Alizarin Red staining after 4 and 8 weeks post-implantation.
Findings: Based on the histological findings, newly formed bone area in scaffolds containing BG/Sr was greater than that without Sr after 8 weeks.
Conclusion: Our results specified that BG/Sr containing scaffolds could better increase bone regeneration than those without Sr and could be considered as a bone graft in bone tissue engineering.
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Article Type: Original Research | Subject: Stem Cells
Received: 2018/06/7 | Accepted: 2019/07/2

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