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Keshavarz M, Khosravy F, Nikbin B, Honarmand M, Sarafnejad A. Study of IgE in children with Steroids Responsive Nephrosis. mjms 2008; 10
URL: http://mjms.modares.ac.ir/article-30-6273-en.html
Study of IgE in children with Steroids Responsive Nephrosis
Maryam Keshavarz 1, Farideh Khosravy2 , Behrouz Nikbin1 , Malektaj Honarmand3 , Abdolfatah Sarafnejad4
1- Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Nephrology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (10303 Views)
Objectives: The idiopathic minimal change nephritic syndrome (nephrosis) is responsible in 80% of nephritic syndromes in children. It is a clinical entity characterized by inter and outer renal parameters. Main factor in glomerolar damages is proteinuria and the role of IgE is possible. Aim: In this research, serum IgE concentrations were measured in children with nephrosis in three stages: Relapse, Remission in treatment with steroids, Remissions after treatment with steroids. Materials and methods: Study was done on children under 16 years old that suffered from nephrosis. They treated with Prednisolone. Serum IgE concentrations were measured by ELISA technique. Results: Average Concentration of serum IgE in the relapse phase was 274.8 Iu/ml (SD=14.6); It was in the remission with steroids treatments 179.59 Iu/ml (SD= 14.82) and it was 234. 9 Iu/ml (SD=14.58) in the remission phase after treatment with steroids. Conclusion: In some cases IgE is significantly reduced after steroid treatment therefore it seems possible that allergic agents can trigger or increase the disease. Serum IgE concentration was not a main factor in nephritic syndrome.
Keywords: IgE, Idiopathic minimal change nephrotic syndrome
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Received: 2007/12/19 | Accepted: 2007/12/19
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