Volume 27, Issue 4 (2024)                   mjms 2024, 27(4): 0-0 | Back to browse issues page

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Jalali F, Alami K, Azizi H. Assessing Inflammatory Pain in Animal Studies: An Overview of the Formalin Test. mjms 2024; 27 (4)
URL: http://mjms.modares.ac.ir/article-30-77830-en.html
Assessing Inflammatory Pain in Animal Studies: An Overview of the Formalin Test
Fatemeh Jalali1 , Kawsar Alami1 , Hossein Azizi 2
1- Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2- Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , azizih@modares.ac.ir
Abstract:   (1057 Views)
Pain, a complex and debilitating experience, significantly impacts the quality of life. It is considered as a primary reason for seeking medical care. Inflammatory pain, resulting from tissue injury, is characterized by the release of inflammatory mediators that activate nociceptive pathways, leading to heightened sensitivity. Assessment of inflammatory pain is necessary for understanding its mechanism and developing effective treatment strategies. This study provides an overview of the formalin test, a widely used animal model for assessing inflammatory pain. The test comprises distinct phases (phase I, interphase, and phase II), which reflect acute and tonic pain responses. As a tool for evaluating analgesic efficacy and pain mechanisms, the formalin test has been instrumental in advancing our understanding of pain biology and the development of novel therapeutic approaches.
Keywords: pain, inflammation, formalin, tonic pain
     
Article Type: Systematic Review | Subject: Neuroscience (General)
Received: 2024/11/4 | Accepted: 2024/12/14
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