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Showing 33 results for Rahbar


Volume 0, Issue 0 (Articles accepted at the time of publication 2024)
Abstract

Tense plays an important and determining role in human verbal communication; therefore, one of the things that should be addressed in language teaching is the discussion of time and ways to recognize it. Considering the role and importance of grammatical tense recognition in language learning and the lack of related research regarding Persian language learning, the purpose of the present research is to investigate the role of available cues in sentences to recognize grammatical tense by Chinese Persian learners of beginner and advanced levels; For this purpose, 49 Persian learners of Chinese language were selected by available sampling method and divided into two groups of Chinese language beginner (26) and advanced (23) based on the level determination test. The instruments used in this research were two tests in two stages; In the first stage, by using the sentence recognition test, the subjects marked the time of the sentences they heard in the answer sheet, and in the second stage, the same test was performed; with the difference that in this test, the sentences did not have time adverbs. The results of this research showed that the subjects of the beginner Chinese language meaningfully used lexical clues when recognizing the time of the sentence, and the subjects of the advanced level simultaneously used two lexical clues and present tense. Regarding the role of gender, the results showed that there is no significant relationship between gender and the ability to understand sentence time. The results of this research can be useful for language learners, teachers, and producers of educational content and also for test designers.
 

Volume 0, Issue 0 (Articles accepted at the time of publication 2024)
Abstract

The current research aims to investigate the universality of the language by examining the perception of Persian learners in recognition of subject position according to the theory of input processing and the principle of the first noun from this theory. The first noun principle indicates that language learners consider the noun or pronoun that comes at the beginning of the sentence as the subject of the sentence.The participants in this research are 70 Persian language learners at elementary (23 participants), intermediate (23 participants) and advanced (24 participants) levels in the Persian language learning center of Al-Zahra University. Using Friedman et al.'s (2004) executive method, this study has examined the principle of the first noun as a predictable path in the education of Persian learners. In this direction, a test has been designed on Google Forms, and Persian learners have participated in two different implementations of this test in a time interval of 5 months. In both of its implementations, this test included 15 sentences that the language learners had to connect to the related pictures after hearing the sentences. In order to characterize the perception of the participants from the position of the subject, 8 sentences in the second sentence were put into the passive form. The results of this study have shown that the change of sentences in the second implementation of the test caused an increase in errors in the response rate of language learners and this was reported higher in elementary language learners than in other groups.

Volume 0, Issue 0 (Articles accepted at the time of publication 2024)
Abstract

Early maladaptive schemas are mentally dysfunctional patterns that are formed since birth following the unfulfillment of human needs. The purpose of this research is to discover the relationship between the early maladaptive schemas of the fourth domain and their coping styles with direct and indirect requests. In general, 18 schemas are formed as a result of five needs not being thoroughly fulfilled in humans. In this research, only the schemas of the fourth domain, are discussed and investigated. Each person copes with their schemas in three different ways. In this research, two coping styles, surrendering and compensation, are examined. To collect data, the request style questionnaire, designed by the researcher, the Young Parenting Inventory (YSQ), and the compensation questionnaires of Young (2003) were handed out online. The participants, 73 males, and 169 females were born from 1981 to 1996, held bachelor's or master's degrees, and lived with both their parents until the age of 18. First, the request-style questionnaire was examined qualitatively according to the theory of Brown and Levinson (1987), and then the research data were analyzed using inferential statistics. According to the findings, the compensation style of domain four schemas has a direct relationship with the direct request, and the surrender style of domain four schemas has a direct relation with the indirect request. Also, gender does not affect direct or indirect request-making.



Volume 2, Issue 6 (Summer 2021)
Abstract

This study aimed to provide a model for improving the quality of women's and girls' leisure time in the family with an approach based on physical activity in Isfahan province. This research was carried out using a qualitative method with a systematic approach of grounded theory. The theoretical population consisted of knowledgeable and experienced women's sports and leisure professors who also used the snowball method for sampling. The data collection tool and method were semi-structured individual interviews, and the interviews continued until the theoretical saturation of 15 interviews. For data analysis, a systematic approach includes three main steps: open coding, axial coding and selective coding. In the axial coding stage, the connection between the following categories of causal conditions (support of important others, organizing, applicability of activities, institutionalization of activities); context factors (environmental attractions, environmental conditions, sports attractions(; interfering factors (evolutionary changes, cultural and social barriers, gender hegemony, macro trends, structural barriers); strategies (education and culture building, measures to support women's recreational sports, promotion and development of physical activities, respect for the dignity of women and girls, justice in the implementation of activities, media support) and consequences of qualifying women's leisure time (reducing behavioral disorders, individual empowerment, collective empowerment, increasing participation) in terms of coding paradigm in Sports manufacturing corporations was determined; also in selective coding phases, each component of coding paradigm described. The province's sports managers can use the signs, concepts and categories identified in their plans to improve the leisure time of women and girls in the family with an approach based on physical activity and use the proposed appropriate strategies to compensate for the backwardness and development of women's sports.

Volume 3, Issue 2 (5-2017)
Abstract

Background: Accessory colonization factor is located immediately adjacent to and downstream of TCP cluster. These genes (acfA, B, C, D) are involved in bacterial colonization and pathogenesis. The aim of this study was to analyze the ACF cluster prevalence rate and gene content in clinical isolates of Vibrio cholerae.
Materials and Methods: All of the 21 V. cholerae isolates used in this study were collected during 2011-2012 outbreaks in Iran. All of the isolates were screened by biochemical tests and confirmed by specific PCR for 16srRNA-23srRNA intergenic space. The gene content of ACF cluster in the isolates was analyzed using 4 primer pairs with overlapping sequences and then subjected into Restriction Fragment Length Polymorphism (RFLP) assay.
Results: Among the 21 V. cholerae isolates, all of them (100%) were identified as V. cholerae O1 Inaba, 20 (95%) isolates were determined with El Tor biotype specificity, and 1 isolate (5%) appeared as Classical biotype. A total of 18 strains (85.8 %) contained a complete set of ACF-associated genes, 3 strains (14.2 %) were negative for ACF cluster, and all of the strains showed similar RFLP pattern to each other and to V. cholerae ATCC 14035.

Conclusion: The results showed that O1 Inaba was the dominant serotype and positive for ACF cluster in pathogenic V. cholerae isolates collected during 2011-2012 in Iran. The presence of some ACF negative strains with potentially pathogenic characteristics proposed that other colonization factors might have been involved in causing pathogenicity and diarrhea in these strains. 

Volume 3, Issue 4 ((Articles in Persian) 2012)
Abstract

This study attempts to evaluate one of the language use differences among women and men according to the Dominance Theory. The main purpose of the study is thus to investigate speech interruption as the participatory dominance factor based on the Dominance Theory in the Persian community and three affecting factors on interruption (direct statements, subject deviation and verbs and adverbs of uncertainty). Speech interruption and three affecting factors on interruption have been evaluated in the single and cross-sex societies. The data required were obtained from 40 two-stage interviews (10 men and 10 women students in the age range of 18-24 years). The men and women of this study in single and cross-sex societies, based on speech interruption factor, showed different linguistic behaviors and the linguistic representation of gender-based attitude in the Persian community was tangible. The relationship of each affecting factor on interruption with interruption was determined. The findings suggest that the framework provided by Dominance Theory in Persian community is inefficient.        

Volume 3, Issue 4 (12-2015)
Abstract

The appearance of sowbugs (Hemilepistus shirazi Schuttz) in the sedimentation basins of the artificial recharge of groundwater (ARG) systems in the Gareh Bygone Plain (GBP) in southern Iran is considered an ecological breakthrough in desertification control. This study was performed at the Kowsar Floodwater Spreading and Aquifer Management Research, Training and Extension Station in GBP, 200 km from the south east of Shiraz, Iran, on the alluvial fan of Bisheh Zard River. Invasion of sowbug to sedimentation of basin due to water increasing persuade us to study about this crustacean. To determine aggregate size distribution, the soil samples were dried, and then the soil was sieved through a set of sieves (8, 4.75, 2.8, 2.0, 1.0, 0.8., 0.3 and

Volume 4, Issue 1 (4-2014)
Abstract

Sheykh Shahāb ad-Dīn Suhrawardī, as one of the great Moslem philosophers and theologian, founded his philosophy upon the doctrine of Illuminationism. His theories and teachings have deeply influenced the beliefs and performances of the Iranian artists. In view of this, the present research aims at investigating Suhravardī’s understanding of Illuminationism and hierarchy of lights. It also tries to trace manifestations of the khorrah light (or the Divine Light), which was of utmost significance in Suhravardī’s doctrine of Illuminationism, in the art of architecture. Finally, it is tried to answer the question “Which elements signify the manifestation of the Light - as conceived of in the Illuminationist Philosophy – in the Iranian-Islamic architecture?” Sheykh of Ishrāq [Suhrawardī] called God ‘the Light of All Lights’ [Nūr-ul-Anwār] and believed that the heaven and earth are made of God’s light; and all beings enjoy His light in proportion to their closeness to His light. He also believed that the light as existing at the stages of sense and matter is inferior to the light that exists in the more exalted stages. That is to say, the closer one gets to the Source of Light - ‘the Light of All Lights’ [Nūr-ul-Anwār] – the purer and brighter the light they get will be. Therefore, separation from the matter translates into moving and getting elevated toward the Source of Being and the Light of Existence and avoiding the lowest levels of existence and shadows. Furthermore, there is an eternal tie between art and philosophy/wisdom. The reason is that they are both perceived intuitively and expressed enigmatically. Therefore, it is through meditation and self-discipline that an artist may attain at that angel-like insight, which is the source of all celestial arts. Such works of arts are the fruits of an artist’s quest in the spiritual world and intuitive perception of the truths there. Like the Divine Knowledge and the doctrine of Illuminationism, the traditional art is expressed in the language of enigma, the very characteristic feature that enables it to establish an association between the most far-fetched inward concepts and the most superficial level of the existence in the outward world. From the above perspective, light is considered the symbol of existence in the sphere of the Islamic Architecture; and due to the fact that the mosque, regarded as the heart of the Islamic Architecture, is where all the secrets and mysteries of this architecture is manifested, the present article deals with the symbols of light in the architecture of mosques. The doctrine of Illuminationism propagated by Suhrawardī and other Illuminationist philosophers has influenced the Iranian culture and art (particularly, during the Timurid and Safavid rules, when Sheykh ‘s ideas were in their heyday). As one can obviously see in their works, Iranian architects had a spiritual approach toward light, like the Illuminationist philosophers of their homeland did. Manifestation of the Divine Light in the form of words of Azān [the Call for Prayers] from minarets, provision of light through envisaging lamps in the epicenter of mihrabs (i.e., the mishkāt), installation of Koranic tablets containing verses from the Nūr Chapter, and the arch-shaped mihrabs and the muqarnases therein…, they all appear to be the incarnation of lights, which symbolize the stage on which the Divine Lights shine. Application of ‘shamsehs’, the arrangement of skylights on the domes, the muqarnases that absorb the light and diffuse it delicately, the latticed windows that let pass the light, the reflection of the light in the bright enameled tiles, continuous vaults, and the colorful glasses, which signify the unity in diversity with their harmonious colors functioning as a medium of transmitting the light, and presence of yellow and gold colors symbolizing the Light of All Lights [Nūr-ul-Anwār] in the terrestrial world…, they all substantiate the fact that the Iranian architects had an Illuniationist viewpoint and practiced under the influence of that doctrine Because the Iranian Architecture is all about light and illumination. The survival of everything hinges upon light. For the purpose of this research, data and information were collected through documentation, the research was conducted on a descriptive basis, and the analysis was made in an analytical fashion. Based on the results obtained, no symbol or manifestation compares to the light in terms of its affinity and propinquity with the Divine Unity. For the same reason, the Muslim Iranian architects have tried their best to use light in whatever they created. Elements like the minarets, mihrabs, muqarnas [corbels], tiles, continuous vaults, colorful glass, and conspicuous presence of yellow and gold colors are all symbols of the Light of All Lights [Nūr-ul-Anwār]. In like manner, the concept of ‘Khorrah’ or the Divine Light has manifested itself in architecture through ‘Shamseh’ and application of latticed surfaces like luminous halos under the domes in the Iranian-Islamic architecture. Therefore, the role of light in the Islamic architecture is to symbolize the Principle of [divine] Manifestation. The utmost function of the elements applied in the architecture is manifestation of God; that is, ‘the Light, and the manifestation of the Ubiquitous Light of the firmaments and the earth, that is, the Only True Being. That is why the Iranian architects would try their best to use the element of light in whatever they created. One of the fundamental notions in Iranian’s Doctrine of Illuminationism on which Suhrawardī placed primary emphasis, is the notion of ‘Khorrah’. ‘Khorrah’ signifies observation of the Divine Lights by the spiritual wayfarers [sālek] in course of their spiritual journey. In the traditional art of Persian miniature, khorrah was is delineated as a halo around the heads of the characters. In architecture, the same has been demonstrated in the form of ‘Shamseh’. The circular layout of the skylights under the domes and the way light enters through the latticed windows clearly conjure up the image of a luminary halo in an emphatic mode. Manifestation of the khorrah light in the form of shamsehs and the skylights of the mosque domes can be regarded as another significant finding of this study.

Volume 4, Issue 1 (Spring 2020)
Abstract

Abstract
Research Subject: In recent years, the use of graphene nanoplatelets (GnPs) in polymer nanocomposites has attracted considerable attention. Dispersion state of GnPs in the polymer matrix has a great importance which can affect microstructure and final properties of nanocomposite. Therefore, in the present work, the effect of compatibilizer on the dispersion state of GnPs and also on internal structure, orientation, and tensile properties of polypropylene (PP)/GnPs nanocomposite fibers are investigated.
Research Approach: PP/GnPs nanocomposite fibers containing 0.1% and 0.5% GnPs with and without
maleic anhydride-grafted polypropylene (PP-g-MA) were melt spun. Dispersion state and location of GnPs in the nanocomposite fibers were investigated by transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). Fiber orientation and crystallinity were studied by polarized Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC), respectively. Moreover, fracture behaviour of PP/GnPs nanocomposite fibers was investigated by cross-sectional scanning electron microscopy (SEM) images of tensile fractured samples. Using Halpin-Tsai model, experimental tensile moduli of fibers were compared with the predicted values. 
Main Results: TEM images show that in the compatibilized PP/MA/GnPs nanocomposite fibers, GnPs aggregates decrease and their size also reduces, suggesting that GnPs dispersion improved. An increase in Lp of the compatibilized sample recorded from SAXS analysis indicates that the more GnPs are located in the intrafibrillar region. Based on polarized FTIR and DSC results, orientation and crystallinity of PP/G0.5 nanocomposite fiber are found to significantly increase after inclusion of PP-g-MA. Moreover, reinforcing effect of GnPs in PP/MA/GnPs nanocomposite fibers could be explained by better GnPs dispersion and changes in internal structure of fiber. Furthermore, the tensile fracture behavior of PP/GnPs nanocomposite fiber changes from ductile to brittle in the presence of PP-g-MA.

Volume 7, Issue 2 (Spring 2018)
Abstract

Aims: The aim of this study was to investigate the effect of Diuron in vitro on the growth rate of Anabaena flos-aquae in order to determine the toxicity of diuron by calculating EC10, EC50, EC90, and MAC value for this alga to control flourishing in this phytoplankton.
Materials and Methods: In this experimental research, the growth rate of Anabaena flos-aquae was investigated under the influence of diuron. This experiment was conducted in 96 days with 6 treatments (0.0005, 0.009, 0.016, 0.03, 0.054, and 0.01 mg/l), 1 control group, and 3 repetitions of the treatments in 500cc Erlenmeyer flasks. The growth rate was measured, using cell counting, turbidimetric measurement, and chlorophyll a measurement methods. Then, achieved quantities of EC were used in four 500cc Erlenmeyer flasks and the concentration of algae was evaluated through cell counting in 24-hours periods during 96 hours. Using SPSS 17 software, one-way ANOVA was used to compare the increase percentages between different treatments.
Findings: Quantities of EC10, EC50, EC90, and Mac value of this toxicant for the algae according to chlorophyll a concentration were reported 0.006, 0.01, 0.05, and 0.001 mg/l, respectively. The frequency of Anabaena flos-aquae was significantly different in presence of concentrations obtained from EC indices and decreased sharply in EC90 quantities.
Conclusion: The use of diuron in the proposed concentrations reduces its risk from the perspective of toxicity and contamination of other components of the ecosystem and it is more effective in this group of algae.


Volume 7, Issue 28 (11-2019)
Abstract

Our accessibility to myths has been limited for us throughout the history for some reasons. Today, most people has the concept of snake as pest and insidious simply for fear of bite and death. For this reason, human beings have come to reflect the continuation of an old tradition belonging to myths whose phenomena are the experiences and truths of people's lives, hidden in a myriad of stories and fantasies over time. This is certainly a combination of self and animals which has the domesticated role and is considered the symbol of power against animals. In relation to Shāmārān’s myth, the relationship between man and the snake has taken over time a new form to the extent that the snake becomes a part of human existence and forms a hybrid being. Shāmarān (half human - half snake), the myth of Kurdish culture, is one of the motives associated with this culture throughout history. In the motives of Kurdish people of Mokriyān, Shāmārān is the goddess of snakes which is the symbol of treasure and wealth attributed to it- an old metaphor of the knowledge it possesses. The myth, the repetition of animal motifs and their frequency of use, reflect the beliefs of the peoples in this culture. The snake is the most sacred symbol of the Kurds and the shāmār represents the material and immaterial knowledge and the conservation of the secrets for the Kurds. The method used in this study is descriptive-analytical and historical in nature, and it has been attempted to describe and compare the role of this animal in different parts of Mokariyān in Mahābād.
The results showed that Shāmārān is the symbol of power, wisdom, blessing, friendship and protection, and its image woven on the crafts of local residents such as the curtain, the handkerchief and the cradle indicates a strong presence.
 
Fatemeh Rahbarizadeh, Vahid Khoddami Vishteh, Davood Ahmadvand,
Volume 10, Issue 0 (بهار 86- 2008)
Abstract

Purpose: The antigen binding fragments of camelids heavy chain antibodies are comprised in one single domain (VHH). The crystal structure of an isolated VHH indicated that it is a problate particle of 2.5 nm in diameter and ∼ 4 nm high, and has been referred to as a nanobody. The very close similarity of these molecules to human VHs illustrates the potential application of these novel products as an immunodiagnostic immunotherapeutic reagent. One of the key components in production, characterization and application of nanobodies in detection is the anti-nanobodiy HRP conjugate. Materials and Methods: Here, we report high expression and purification of some nanobodies against tumor markers. The nanobodies genes were sub-cloned into a pSJF9 vector to over-express the protein coupled with fusion tags in E. coli TG1. The expressed nanobodies were purified by immobilized metal affinity chromatography (IMAC). Described here is the preparation, purification and characterization of anti-nanobody antibody HRP conjugate for use in the various nanobody detection systems. Results: Analysis by SDS-PAGE and Western blotting demonstrated the integrity of the purified nanobodies. Because of application of several biochemical modifications, the produced anti-nanobodies HRP conjugate have efficient sensitivity and specificity. Conclusion: By setting the temperature, time and inducer reagent the nanobodies were produced in optimum yield. We concluded that the HRP conjugated anti-nanobody can detect nanobodies in various detection procedures with great sensitivity and accuracy.

Volume 11, Issue 2 (Vol. 11, No. 2 (Tome 56), (Articles in Persian) 2020)
Abstract

The linguistic variety spoken by the prisoners and the words and expressions used by them in their conversations has attracted a lot of attention. This variety is sometimes so different from the one used outside the prison walls that it is almost unfathomable for those who have never been exposed to it. This variety is idiosyncratic in terms of phonology, morphology, and semantics. The study of prison language and its relevant words and expressions is of great significance from sociolinguistic, psycholinguistic, cognitive linguistic, and criminology points of views. Due to significance and the paucity of domestic linguistic studies on the prison language, this study, within the framework of sociolinguistics, made an attempt to bring the semantic features into considerations and delve into the semantic changes of related words and expressions in the prison language with respects to the four variables of gender, age, education, and social status and respond to the following two research questions: First, What are the main semantic changes of words and expressions in the language of prison? Second, what are the relationships between semantic changes and the four variables of gender, age, education, and social status? In order to collect the data, observation and interviews were utilized. The data included 615 and 496 idioms and expressions used by male and female prisoners respectively (total expressions amounted to 1111). The number of all interviewees was 70, consisting of 20 females from Rey Prison and 50 males from four prisons of Raja’ee Shahr, Ghezelhesar, Fashafooye, and Tehran. The results showed that four semantic processes of metaphor, Irony, metonymy, and semantic degradation accounted for the main sources of semantic changes of words and expressions in the language of prison. Regarding the effects of the four variables of gender, age, education, and social status on these semantic processes, it was concluded that gender did not bring about any significant change in the speech of male and female prisoners, though it was effective on the frequency of use of those semantic processes. Some expressions were specific only to men and some were female specific. Out of the other three variables (age, education, and social status), the two variables of education and social status had the most effects on the use of semantic changes among the prisoners. The effect of age is more than that of social status and education and is less than that of gender. In sum, it can be concluded that as education and social status increase, the use of words and expressions in the language of prison decreases. In contrast, as education and social status decrease, the prisoners are more influenced by the language of prison and they use more semantic processes in their speech.
Samila Farokhimanesh, Fatemeh Rahbarizadeh, Abbas Kamali, Gholamreza Moghaddampour,
Volume 12, Issue 2 (6-2009)
Abstract

Objective: The greatest challenge in cancer gene therapy is to achieve the high specificity and efficiency in targeting of cancer cells. Because the goal of cancer gene therapy is to eradicate cancer cells, many therapeutic genes could be detrimental if unintentionally expressed in normal cells. Using promoter of the genes which are expressed specifically in cancer cells or have much more expression in cancer cells than normal cells, is very noticeable tool in cancer gene therapy (CGT). In this study we were searching for cancer specific promoter which could highly express therapeutic gene. Materials and methods: In order to apply a cancer specific promoter for creating a CGT construct, a promoter which have 34% similarity to Survivin core promoter was amplified from human genome by using Nested-PCR. Survivin is a member of anti-apoptotic gene and its over-expression was observed in up to 70% of breast cancers. This gene fragment contains two transcriptional binding sites which were similar to Survivin promoter according to the evaluation of Promoter Scan, EPD, Transfac, Compel and TRRD program. These binding sites were recognized by STAT1 and E2F transcription factors. This promoter was cloned into pCDNA3.1/Hygro+ plasmid in along with hypoxia and estrogen modules and pro-apoptotic gene tBid. Results: Semi-quantitative RT-PCR results of transfected cancer cells showed that this gene fragment (Survivin like promoter) have relatively same potential as CMV promoter to direct tBid gene expression. Conclusion: Utilization of chimeric promoter containing Survivin like promoter could be a promising tool in killing cancer cells naturally by inducing apoptosis. This construct is highly effective in transcriptional targeting of tBid in comparison to control construct.
Mehdi Mahdavi, Massoumeh Ebtekar, Kayhan Azadmanesh, Fereidoun Mahboudi, Hamidreza Khorram Khorshid, Fatemeh Rahbarizadeh, Adel Mohammadzadeh, Zohair Hassan,
Volume 12, Issue 4 (10-2010)
Abstract

Objective: Today, AIDS is considered as a global problem and many efforts to generate an effective vaccine against this disease have been made, but remain inconclusive. DNA vaccines are a member of the new generation of vaccines that can efficiently stimulate the immune system. However, recent findings indicate low immunogenicity for these vaccines and it is believed that these types of vaccines require strategies that could infer more immunogenicity. The employment of adjuvants could be considered as one of the most important methods involved. In this study, a DNA vaccine candidate for HIV P24-Nef is constructed and then using genetic adjuvants IL-15 and GM-CSF, cellular immune responses have been studied. Materials and Methods: In this study the gene structure of HIV P24-Nef in eukaryotic expression vector was constructed and expression vectors of IL-15 and GM-CSF were used as adjuvants. After inoculation of the candidate vaccine to BALB/c mice, cytokine patterns, lymphocytes proliferation and cytotoxicity were analyzed. Results: Our findings indicate that candidate vaccine significantly stimulated cellular immune responses. The usage of IL-15 and GM-CSF as DNA adjuvants together and separately with candidate vaccine has strengthened cellular immune responses significantly. Co-administration of DNA adjuvants significantly increased cellular immune responses when the ratio of the vaccine dose was more than the adjuvants. Conclusion: The sequences that we selected as candidate vaccine demonstrated good immunogenicity in mouse model and co-administration of IL-15 and GM-CSF DNA adjuvants increased cellular immune response to DNA vaccine construct.
Mehdi Mahdavi, Massoumeh Ebtekar, Kayhan Azadmanesh, Fereidoun Mahboudi, Hamidreza Khorramkhorshid, Fatemeh Rahbarizadeh, Amir Nejadmoghaddam, Zuhair Hassan,
Volume 13, Issue 2 (4-2010)
Abstract

Objective: Several vaccines against HIV have been investigated but none has been approved as an effective HIV vaccine. An approach that could induce stronger immune response against the pathogen is utilizing a multi-epitopic vaccine. This strategy was used in the design of several vaccines and resulted in improved immune responses. Materials and Methods: In this study a multi-epitopic fusion peptide including parts of HIV-1 Nef and P24 as a vaccine candidate was injected into mice and immune humoral responses measured with total antibody and IgG sub-classes using ELISA. Also measurement of cellular immune responses through evaluation of spleen cells proliferation response using MTT and cytotoxicity by LDH were performed. Finally, the cytokine pattern of IFN-γ and IL-4 were also determined with ELISA. Results: The results indicate that candidate vaccine stimulated mouse splenic lymphocyte proliferation response and also induced strong cytotoxicity responses. Analysis of humoral immune response has shown that the candidate vaccine has induced specific antibody production mainly of the IgG2a sub-class. Also cytokine pattern evaluation has shown that IFN-γ secretion was dominant. Conclusion: The use of immunogen and conserved epitopes from P24 and Nef induced strong humoral and cellular immune responses and this construct could be candidate for further studies in animal models.

Volume 13, Issue 4 (September & October 2022)
Abstract

This study is to investigate forensic discourse analysis of the facility contracts like Murabaha, Jaaleh, civil participation and installment sale.The aim of this research is to probe the forensic discourse analysis of the aforementioned texts in the field of forensic linguistics by considering the Van Leeuwen ’s 1996. To do that, the quantity, quality and the mystification of each contract ’s text was probed to discover the factors which ruin the clarity of those texts. The qualitative method of discourse analysis was used to explore the hypothesis of this research. The discoursal elements in the Van Leeuwen ’s (1996) were extracted and the mystification of each contract and different manipulations in each article of contracts were analyzed by using version 21 of SPSS software. The frequency and the percentage of their occurrence was found. The result shows that significant explicit, implicit elements and mystifications in all contracts were seen. The least frequency of explicit elements in the text of Jaaleh by the frequency of 20and the most number of mystification can be observed in the mentioned text by 81.3 percent. The manipulation based on threat was seen 11 times in Murrabeh, Jaaleh. It can be concluded that based on the occurrence of the implicit elements and mystification of all texts of the facility contracts, using implicit elements should be avoided.Consequently, the ambiguity and the mystification will be reduced. The result of the present study helps the banks’ legal experts to write the contracts more apprehensible with less ambiguity.

 1. Introduction
Since all the facility contracts are assumed as legal documents, lack of clarity in their texts lead to serious challenges in terms of perception for the two sides of the contract; subsequently it will be a crucial concern for the bank facilities’ applicants. The significant of the present study is rooted in the afore-mentioned concept and its necessity is the revival of the rights of the bank as the donator of the facility and the customer as its receiver. Therefore, in doing so, the researcher tried to investigate discourse analysis of these facility contracts in the area of forensic linguistics by studying the socio-semantic components and their manipulations.
This study is designed based on Van Leeuwen’s theoretical framework on socio-semantic components (1996) and also the different manipulations of the facility contract texts. The researcher tried to find the suitable answer for these research questions:
  1. Is there any difference between the frequency of explicit elements in facility contract texts of Tejarat Bank?
  2. Is there any difference between the frequency of implicit elements in facility contract texts of Tejarat Bank?
  3. Is there any difference between the frequency of mystification elements in facility contract texts of Tejarat Bank?
  4. Is there any difference between the frequency of manipulation elements in facility contract texts of Tejarat Bank?

2. Literature Review
Theoretical framework applied in this research is Van Leewen socio-semantic components and manipulation of the texts. Also, the studies of the Iranian and foreigner researchers in the areas of forensic linguistics and forensic discourse analysis were reviewed here as Shuy (2001), Shuy (2010). Olsson (2009), Coulthard(2000), Aghagolzadeh(2005), Aghagolzadeh and Farazandehpour (2016), Taghipour (2015) and Habibi (1995).
3. Methodology
In order to find the answers of the research questions, the researcher used the descriptive-analytic method of research. The related data of this study was driven from the most used facility contracts of Tejarat Bank which are: Jallleh, Murabaha, Civil Participation , and Installment Sale
The aim of this study is an investigation of the arrangement of socio-semantic components and manipulations of banking facility contracts. So, the socio-semantic components of Van Leeuven model and manipulation of the paragraphs of each facility contract was found and by using the 21st version of SPSS, their frequency and the percentage were analyzed. Also, by using the socio-semantic components, the mystification of the facility contracts was estimated. The results of the above mentioned analyses were shown in different tables. In the next step, the socio-semantic elements and the mystification of the facility contracts were compared to find which facility contract has the most density of implicit components and subsequently has the most mystification in its text. So, by revising these contracts and omitting the implicit elements, we would be able to increase their clarity.

4. Results
The first two research questions were investigating the difference between the frequency of the implicit and explicit socio-semantic components in the texts of the banking facilities contracts. The results had been proven that the frequency of the implicit components in the text of Jaaleh contract is more than the other contracts. So, the first and second research hypothesis had been had been proven. The third research question was the comparison between the mystification of the facility contracts. Also, the facility contract of Jaaleh had the most number of implicit components so its mystification was more than the other contracts. Therefore, by probing those analysis, we can conclude that we should reduce the number of implicit components to reduce the mystification of the contracts as it may cause the creation of unclarity and it may cause legal problems for the customers of the bank.
Finally, it is concluded that the threatening manipulation could be observed in all the contracts; however, encouraging manipulation could be observed only in text of Morabehe contract. It means that in banking system of Iran, we assume only threatening as the only tool. So, the fourth hypothesis was proven, too.

Volume 13, Issue 4 (1-2023)
Abstract

Immunotoxins are an attractive way to treat cancer; in this method, high-cytotoxic protein toxins target cancer cells specifically. An immunotoxin consists of a targeting component (an antibody, cytokine, or other protein that binds to the cell), that is chemically conjugated or fused in DNA level to a cytotoxic cargo (a bacterium, plant or cytotoxic human protein). Immunotoxin, with the help of specific receptors, recognizes the target cell and enters the cell by endocytosis. After entering the cytocell, it kills the target cancer cell with the help of a toxic component. Although various immunotoxins with different structures have been studied and tested in recent decades, only three immunotoxins Denileukin Diftitox, Tagraxofusp and Moxestumomab Pasudotox - have been clinically approved for the treatment of leukemia. In this article, we review important research and two challenges in production and development of immunotoxins that have limited their clinical success. Further, we highlight methods to overcome these obstacles. These challenges include target and non-target cell toxicity and immunization.
Fatemeh Safarian, Fatemeh Rahbarizadeh, Said Amanpour, Zahra Sharifzadeh,
Volume 14, Issue 2 (6-2011)
Abstract

Objective: The objective of this study is to develop and assess targeted PAMAM-PEG nanocarrier with anti-TAG72 nanobody for t-Bid gene coding construct delivery into the human colonic adenocarcinoma cells. Materials and Methods: Nanobody (Nb) coding sequence was subcloned into pSJ expression vector for large-scale production and then Nb was purified by Ni++ affinity chromatography. SDS-PAGE and western blot analysis were performed to verify purifiction. PAMAM was reacted with PEG at the ratio 1:2 (mol/mol) and anti-TAG72 Nb at the ratio 1:1 (mol/mol). Surface charge and size of resulting nanoparticles were evaluated by Malvern zeta sizer and Nanosight. Efficiency of constructed gene carrier for t-Bid, a killer gene, delivery into colonic adenocarcinoma cells in in vitro was assessed using real time PCR and cell counting assays. Results: Production of nanoparticles with the average size of 162±92 nm and +4.57±0.52 zeta potential was confirmed by nanosight and Malvern zeta sizer in order. Gel retardation assay result verified efficiency of carrier for pDNA comlexation. Real time PCR results confirmed the target gene overexpression in the cancerous cell lines. Conclusion: The results of this research confirms the efficiency of PAMAM dendrimers for gene transferring, positive effect of PEGylation and targeting of nanoparticles by anti-TAG72 nanobody.

Volume 15, Issue 5 (7-2015)
Abstract

Non-Newtonian fluid flows experience turbulent regime in some industrial applications. Several approaches have been proposed for numerical simulation of turbulent flows that each one has specific features. RANS turbulence models have reasonable computational costs, while include several sources of uncertainties affecting simulation results. In addition, developed RANS models for non-Newtonian fluids are modified versions of available models for Newtonian fluids, therefore, they cannot provide reliable estimation for viscoplastic stress term. On the contrary, DNS delivers accurate results but with high computational costs. Consequently, use of DNS data for estimation of uncertainty in RANS models can provide better decision making for engineers based on RANS results. In the present study, a turbulence model based on for power-law non-Newtonian fluid is developed and employed for simulation of flow in a pipe. Then, an efficient method is proposed for quantification of available model-form uncertainty. Moreover, it is assumed that uncertainties originating from various sources are combined together in calculation of Reynolds stress as well as viscoplastic stress. Deviation of the stresses, computed using RANS turbulence model, from DNS data are modeled through Gaussian Random Field. Thereafter, Karhunen-Loeve expansion is employed for uncertainty propagation in simulation process. Finally, the effects of these uncertainties on RANS results are shown in velocity field demonstrating the fact that the presented approach is accurate enough for statistical modeling of model-form uncertainty in RANS turbulence models.

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