Volume 22, Issue 3 (2019)                   mjms 2019, 22(3): 113-120 | Back to browse issues page

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Nejati S, Imani R, Sharifi A. Synthesis and Characterization of Two Sustained Release Systems of Micro- and Nano-sized Particles for Controlled Release of Atorvastatin for Bone Tissue Engineering Applications. mjms. 2019; 22 (3) :113-120
URL: http://mjms.modares.ac.ir/article-30-20850-en.html
1- Biomaterial Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran
2- Amirkabir University of Technology, NO 350, Hafex Street, Valiasr Square, Tehran, Iran , r.imani@aut.ac.ir
3- Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (6665 Views)
Aims: Using osteoinductive agents in combination with tissue engineering scaffolds is considered as a new approach to bone repair. Recently, statins have attracted great attention among a variety of drugs used in bone repair. In order to achieve a sustained release of Atorvastatin from bone scaffolds, two systems, including nanoniosomes and gelatin microspheres, were synthesized and compared.
Materials and Methods: Nanoniosomes and gelatin microspheres were prepared by thin-film hydration and single emulsion technique, respectively.
Findings: The prepared systems were characterized for morphology, size, carriers’ preparation efficiency, encapsulation efficiency, and drug loading. Also, release profiles of them were evaluated over a period of one week. The results indicated the formation of relatively spherical niosomes with the diameter of about 653.52nm and encapsulation efficiency of 81.34%, and formation of gelatin microspheres with the diameter of about 37.5μm and the encapsulation efficiency of 78.93%.
Conclusion: The results showed that gelatin microspheres had a lower burst release than niosomes, and niosomes had more sustained release than gelatin microspheres after 24hr to 1 week. Albeit, selection of the optimal system requires cellular studies and also the selection must occur according to the severity of the damage and the rate of repair.
 
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Article Type: Original Research | Subject: Tissue Engineering
Received: 2018/05/14 | Accepted: 2019/03/14

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