Volume 21, Issue 1 (2018)                   mjms 2018, 21(1): 29-34 | Back to browse issues page

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Fatahi B, Habibian M. Effect of Aerobic Exercise on Renal Angiotensin-II and Angiotensin Type 1 Receptor Levels in Administered Rats with Nano Zinc Oxide. mjms. 2018; 21 (1) :29-34
URL: http://mjms.modares.ac.ir/article-30-22503-en.html
1- Physical Education Department, Human Sciences Faculty, Sari Branch, Islamic Azad University, Sari, Iran
2- Physical Education Department, Human Sciences Faculty, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran
Abstract:   (6754 Views)
Aim: Zinc oxide nanoparticles are known as important metal oxide nanoparticles and are used in many medical and biological fields, but concerns are rising due to their potential effects on some organs. The aim of this study was to investigate the effect of aerobic exercise on renal angiotensin-II and angiotensin type 1 receptor levels in administered Rats with Nano Zinc Oxide.
Materials and Methods: In this experimental research, 35 male Wistar rats were randomly divided into control, salin, nano zinc oxide, exercise and exercise plus nano zinc oxide groups. Zinc nitric oxide (1mg/kg) was injected intraperitoneally, 5 days a week into exercise and exercise plus nano zinc oxide groups. The exercise program consisted of progressive running on a treadmill (5 sessions per week for 4 weeks). Two days after the last application, the rats were euthanized. The kidney tissue is separated and angiotensin-II and angiotensin type 1 receptor were measured. Data were analyzed by SPSS 20 software using one-way ANOVA and Tukey’s post hoc test.
Findings: After 4 weeks of chronic treatment with nano zinc oxide, the levels of angiotensin-II and angiotensin type 1 were significantly increased. Exercise significantly reduced renal angiotensin II and angiotensin type 1 levels. However, these variable levels in exercise plus nano zinc oxide group still were significantly higher than control group (p<0.05).
Conclusion: Aerobic exercise reduces renal angiotensin II and angiotensin type 1 levels in Administered Rats with nano zinc oxide.
Full-Text [PDF 392 kb]   (918 Downloads)    
Article Type: Original Research | Subject: Sport physiology
Received: 2018/06/27 | Accepted: 2018/06/27

References
1. Chung HE, Yu J, Beak M, Lee JA, Kim MS, Kim SH, et al. Toxicokinetics of zinc oxide nanoparticles in rats. J ‎Phys Conf Ser. 2013;429:012037.‎ [Link]
2. Djurisić AB, Leung YH. Optical properties of ZnO nanostructures. Small. 2006;2(8-9):944-61.‎ [Link] [DOI:10.1002/smll.200600134]
3. Chen W, Zhang J. Using nanoparticles to enable simultaneous radiation and photodynamic therapies for ‎cancer treatment. J Nanosci Nanotechnol. 2006;6(4):1159-66.‎ [Link] [DOI:10.1166/jnn.2006.327]
4. Møller P, Jacobsen NR, Folkmann JK, Danielsen PH, Mikkelsen L, Hemmingsen JG, et al. Role of oxidative ‎damage in toxicity of particulates. Free Radic Res. 2010;44(1):1-46.‎ [Link]
5. Greish K. Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. ‎Methods Mol Biol. 2010;624:25-37.‎ [Link] [DOI:10.1007/978-1-60761-609-2_3]
6. Zheng Y, Li R, Wang Y. In vitro and in vivo biocompatibility studies of ZnO nanoparticles. Int J Mod Phys B. ‎‎2009;23(06n07):1566-71.‎ [Link]
7. Yan G, Huang Y, Bu Q, Lv L, Deng P, Zhou J, et al. Zinc oxide nanoparticles cause nephrotoxicity and kidney ‎metabolism alterations in rats. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(4):577-88.‎ [Link]
8. Buzea C, Pacheco II, Robbie K. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases. ‎‎2007;2(4):MR17-71.‎ [Link] [DOI:10.1116/1.2815690]
9. Faddah LM, Abdel Baky NA, Al-Rasheed NM, Al-Rasheed NM, Fatani AJ, Atteya M. Role of quercetin and ‎arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. BMC Complement Altern Med. ‎‎2012;12:1060.‎ [Link]
10. Brewster UC, Perazella MA. The renin-angiotensin-aldosterone system and the kidney: Effects on kidney ‎disease. Am J Med. 2004;116(4):263-72.‎ [Link] [DOI:10.1016/j.amjmed.2003.09.034]
11. Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev. ‎‎2006;86(3):747-803.‎ [Link] [DOI:10.1152/physrev.00036.2005]
12. Navar LG, Harrison-Bernard LM, Imig JD, Cervenka L, Mitchell KD. Renal responses to AT1 receptor ‎blockade. Am J Hypertens. 2000;13(1 Pt 2):45S-54.‎ [Link]
13. Navar LG, Kobori H, Prieto-Carrasquero M. Intrarenal angiotensin II and hypertension. Curr Hypertens ‎Rep. 2003;5(2):135-43.‎ [Link]
14. Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, et al. Angiotensin II receptors and ‎angiotensin II receptor antagonists. Pharmacol Rev. 1993;45(2):205-51.‎ [Link]
15. Durvasula RV, Petermann AT, Hiromura K, Blonski M, Pippin J, Mundel P, et al. Activation of a local tissue ‎angiotensin system in podocytes by mechanical strain. Kidney Int. 2004;65(1):30-9.‎ [Link]
16. Liebau MC, Lang D, Böhm J, Endlich N, Bek MJ, Witherden I, Mathieson PW, et al. Functional expression ‎of the renin-angiotensin system in human podocytes. Am J Physiol Renal Physiol. 2006;290(3):F710-9.‎ [Link]
17. Barretti DL, Magalhães Fde C, Fernandes T, do Carmo EC, Rosa KT, Irigoyen MC, et al. Effects of aerobic ‎exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain. PLoS One. ‎‎2012;7(10):e46114.‎ [Link]
18. Leite LH, Lacerda AC, Marubayashi U, Coimbra CC. Central angiotensin AT1-receptor blockade affects ‎thermoregulation and running performance in rats. Am J Physiol Regul Integr Comp Physiol. ‎‎2006;291(3):R603-7.‎ [Link] [DOI:10.1152/ajpregu.00038.2006]
19. Oliveira V, Akamine EH, Carvalho MH, Michelini LC, Fortes ZB, Cunha TS, et al. Influence of aerobic ‎training on the reduced vasoconstriction to angiotensin II in rats exposed to intrauterine growth restriction: ‎Possible role of oxidative stress and AT2 receptor of angiotensin II. PLoS One. 2014;9(11):e113035.‎ [Link]
20. Ciampone S, Borges R, de Lima IP, Mesquita FF, Cambiucci EC, Gontijo JA. Long-term exercise attenuates ‎blood pressure responsiveness and modulates kidney angiotensin II signalling and urinary sodium excretion ‎in SHR. J Renin Angiotensin Aldosterone Syst. 2011;12(4):394-403.‎ [Link] [DOI:10.1177/1470320311408750]
21. Podhorska-Okolow M, Dziegiel P, Murawska-Cialowicz E, Saczko J, Kulbacka J, Gomulkiewicz A, et al. ‎Effects of adaptive exercise on apoptosis in cells of rat renal tubuli. Eur J Appl Physiol. 2007;99(3):217-26.‎ [Link]
22. Zamo FS, Barauna VG, Chiavegatto S, Irigoyen MC, Oliveira EM. The renin-angiotensin system is ‎modulated by swimming training depending on the age of spontaneously hypertensive rats. Life Sci. ‎‎2011;89(3-4):93-9.‎ [Link] [DOI:10.1016/j.lfs.2011.05.004]
23. Kim YR, Park JI, Lee EJ, Park SH, Seong NW, Kim JH, et al. Toxicity of 100 nm zinc oxide nanoparticles: A ‎report of 90-day repeated oral administration in Sprague Dawley rats. Int J Nanomedicine. 2014;9(Suppl ‎‎2):109-26.‎ [Link]
24. Isapare N, Kesmati M, Mohammadi T. The effect of chronic administration of conventional and nano-‎sized zinc oxide on the hippocampus tissue of adult male mice. J Zanjan Univ Med Sci Serv. 2015;23(101):77-‎‎87. [Persian]‎ [Link]
25. Habibian M, Sobhi N. Independent and combined effect of aerobic exercise and garlic extract on the level ‎of renal vascular endothelial growth factor and transforming growth factor-β1 in the eldely rats. J Gorgan ‎Univ Med Sci. 2017;19(2):11-6. [Persian]‎ [Link]
26. Xiao L, Liu C, Chen X, Yang Z. Zinc oxide nanoparticles induce renal toxicity through reactive oxygen ‎species. Food Chem Toxicol. 2016;90:76-83.‎ [Link] [DOI:10.1016/j.fct.2016.02.002]
27. Noori A, Karimi F, Fatahian S, Yazdani F. Effects of zinc oxide nanoparticles on renal function in mice. Int J ‎Biosci. 2014;5(9):140-6.‎ [Link]
28. Esmaeillou M, Moharamnejad M, Hsankhani R, Tehrani AA, Maadi H. Toxicity of ZnO nanoparticles in ‎healthy adult mice. Environ Toxicol Pharmacol. 2013;35(1):67-71.‎ [Link]
29. Saliani M, Jalal R, Goharshadi EK. Mechanism of oxidative stress involved in the toxicity of ZnO ‎nanoparticles against eukaryotic cells. Nanomed J. 2016;3(1):1-14.‎ [Link]
30. Sharma V, Singh P, Pandey AK, Dhawan A. Induction of oxidative stress, DNA damage and apoptosis in ‎mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res. 2012;745(1-2):84-91.‎ [Link] [DOI:10.1016/j.mrgentox.2011.12.009]
31. Brown AM, Kristal BS, Effron MS, Shestopalov AI, Ullucci PA, Sheu KF, et al. Zn2+ inhibits alpha-‎ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase ‎complex. J Biol Chem. 2000;275(18):13441-7.‎ [Link]
32. Welch WJ, Blau J, Xie H, Chabrashvili T, Wilcox CS. Angiotensin-induced defects in renal oxygenation: ‎Role of oxidative stress. Am J Physiol Heart Circ Physiol. 2005;288(1):H22-8.‎ [Link] [DOI:10.1152/ajpheart.00626.2004]
33. Chabrashvili T, Kitiyakara C, Blau J, Karber A, Aslam S, Welch WJ, et al. Effects of ANG II type 1 and 2 ‎receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Am J Physiol Regul Integr Comp ‎Physiol. 2003;285(1):R117-24.‎ [Link]
34. Ghodsi SZ, Jafari M, Feizi GR, Farokhi F, Hashemvarzi SA, Jafari B. Effect of eight-week swimming on ‎angiotensin II and its receptor in renal tissue of elderly rats. Int j Sport Stud. 2016;6(1):58-61.‎ [Link]
35. Hoch NE, Guzik TJ, Chen W, Deans T, Maalouf SA, Gratze P, et al. Regulation of T-cell function by ‎endogenously produced angiotensin II. Am J Physiol Regul Integr Comp Physiol. 2009;296(2):R208-16.‎ [Link]
36. Habibian M, Peeri M, Azarbayjani M, Hedayati M. Protective effect of aerobic exercise against some of ‎proinflammatory cytokines-induced chronic nitric oxide synthase inhibition in renal tissue rats. J Babol Univ ‎Med Sci. 2013;15(1):30-7. [Persian]‎ [Link]
37. Silva SD Jr, Zampieri TT, Ruggeri A, Ceroni A, Aragão DS, Fernandes FB, et al. Downregulation of the ‎vascular renin-angiotensin system by aerobic training -focus on the balance between vasoconstrictor and ‎vasodilator axes-. Circ J. 2015;79(6):1372-80.‎ [Link]
38. Clayton SC, Curry PL, Li Y, Zucker IH. Exercise training and renal denervation attenuate the expression of ‎angiotensin II Type 1 and 2 receptors in rabbits with chronic heart failure. FASEB J. 2008;22(2 Supplement).‎ [Link]
39. Sakuyama A, Ito O, Ogawa Y, Komatsu M, Hu G, Miura T, et al. Abstract P115: Effects of exercise training ‎on renal damage and renin-angiotensin system in dahl salt-sensitive rats. Hypertension. 2015;66(Suppl ‎‎1):AP115.‎ [Link]
40. Vaziri ND. Causal link between oxidative stress, inflammation, and hypertension. Iran J Kidney Dis. ‎‎2008;2(1):1-10.‎ [Link]