Volume 22, Issue 4 (2019)
mjms 2019, 22(4): 221-227 |
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Hejazi K, Attarzadeh Hosseini S, Fathi M, Mosaferi Ziaaldini M. Response of Serum Levels of Adiponectin and Insulin Resistance Indexes in Obese Male Rats to Two Types of Aerobic Exercise Intensities. mjms 2019; 22 (4) :221-227
URL: http://mjms.modares.ac.ir/article-30-39271-en.html
URL: http://mjms.modares.ac.ir/article-30-39271-en.html
1- Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran , k.hejazi@hsu.ac.ir
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
Abstract: (2297 Views)
Aims: Adiponectin is mainly produced by adipose tissue and there is an inverse relationship between circulating adiponectin levels and metabolic syndrome, obesity, and cardiovascular disease. The aim of the current study was to investigate the effects of eight weeks aerobic exercise with moderate and high intensities on serum levels of adiponectin and insulin resistance indexes in obese male rats.
Materials & Methods: In this experimental study, 24 adult obese male Wistar rats (weight 250 to 300g, BMI>30g/cm2) are divided into three groups including aerobic exercise with 28m/min (MI= moderate intensity), aerobic exercise with 34m/min (HI= high intensity) and, control group (C= control). All training groups carried out exercise training for 8 weeks (5 sessions per week for 60 min per session). T-test and one-way analysis of variance were used to evaluate the differences between intra- and intergroup means, respectively. Tukey test was applied to compare the groups as two by two.
Findings: The levels of adiponectin in MI group (p= 0.04) and HI (p= 0.04) rather than C group were increased. Moreover, there are no differences between eight weeks aerobic exercise with MI and HI groups on adiponectin levels (p= 1.00). The levels of FBS and insulin in MI and HI groups rather than C group were reduced but these changes were not significant (p>0.05). The levels of insulin resistance index in MI group (p= 0.01) and HI (p= 0.01) rather than C group were significantly reduced.
Conclusion: It seems that both of the aerobic exercise intensities have a better effect on the prevention of obesity and cardiovascular disease.
Materials & Methods: In this experimental study, 24 adult obese male Wistar rats (weight 250 to 300g, BMI>30g/cm2) are divided into three groups including aerobic exercise with 28m/min (MI= moderate intensity), aerobic exercise with 34m/min (HI= high intensity) and, control group (C= control). All training groups carried out exercise training for 8 weeks (5 sessions per week for 60 min per session). T-test and one-way analysis of variance were used to evaluate the differences between intra- and intergroup means, respectively. Tukey test was applied to compare the groups as two by two.
Findings: The levels of adiponectin in MI group (p= 0.04) and HI (p= 0.04) rather than C group were increased. Moreover, there are no differences between eight weeks aerobic exercise with MI and HI groups on adiponectin levels (p= 1.00). The levels of FBS and insulin in MI and HI groups rather than C group were reduced but these changes were not significant (p>0.05). The levels of insulin resistance index in MI group (p= 0.01) and HI (p= 0.01) rather than C group were significantly reduced.
Conclusion: It seems that both of the aerobic exercise intensities have a better effect on the prevention of obesity and cardiovascular disease.
Article Type: Original Research |
Subject:
Sport physiology
Received: 2019/12/24 | Accepted: 2020/05/9
Received: 2019/12/24 | Accepted: 2020/05/9
References
1. Tyrovolas S, Koyanagi A, Olaya B, Ayuso‐Mateos JL, Miret M, Chatterji S, et al. Factors associated with skeletal muscle mass, sarcopenia, and sarcopenic obesity in older adults: A multi‐continent study. J Cachexia, Sarcopenia Muscle. 2016;7(3):312-21. [Link] [DOI:10.1002/jcsm.12076]
2. García‐Esquinas E, José García‐García F, León‐Muñoz LM, Carnicero JA, Guallar‐Castillón P, Gonzalez‐Colaço Harmand M, et al. Obesity, fat distribution, and risk of frailty in two population‐based cohorts of older adults in S pain. Obesity. 2015;23(4):847-55. [Link] [DOI:10.1002/oby.21013]
3. Keller KL, Pietrobelli A, Faith MS. Genetics of food intake and body composition: Lessons from twin studies. Acta Diabetologica. 2003;40(1):s95-100. [Link] [DOI:10.1007/s00592-003-0038-6]
4. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow-up report on the diagnosis of diabetes mellitus. Diabet Spectr. 2004;17(1):51-9. [Link] [DOI:10.2337/diaspect.17.1.51]
5. Vu V, Riddell MC, Sweeney G. Circulating adiponectin and adiponectin receptor expression in skeletal muscle: Effects of exercise. Diabet Metab Res Rev. 2007;23(8):600-11. [Link] [DOI:10.1002/dmrr.778]
6. Arita Y, Kihara Sh, Ouchi N, Takahashi M, Maeda K, Miyagawa JI, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and biophysical research communications. 1999;257(1):79-83. [Link] [DOI:10.1006/bbrc.1999.0255]
7. Weyer Ch, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86(5):1930-5. [Link] [DOI:10.1210/jcem.86.5.7463]
8. Yokoyama H, Emoto M, Araki T, Fujiwara S, Motoyama K, Morioka T, et al. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes. Diabet Care. 2004;27(7):1756-8. [Link] [DOI:10.2337/diacare.27.7.1756]
9. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. New Engl J Med. 2004;350(23):2362-74. [Link] [DOI:10.1056/NEJMoa031049]
10. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex. Diabetologia. 2003;46(4):459-69. [Link] [DOI:10.1007/s00125-003-1074-z]
11. Giahi L, Djazayery A, Rahimy A, Rahmany M, Larijani B. Serum level of adiponectin and its association with insulin sensitivity in overweight diabetic and non-diabetic Iranian men. Iran J Public Health. 2008;37(2):88-92. [Link]
12. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Investig. 2000;106(4):473-81. [Link] [DOI:10.1172/JCI10842]
13. Vafaeimanesh J, Parham M, Norouzi S, Hamednasimi P, Bagherzadeh M. Insulin resistance and coronary artery disease in non-diabetic patients: Is there any correlation?. Casp J Intern Med. 2018;9(2):121-6. [Link]
14. Rees A, Thomas N, Brophy S, Knox G, Williams R. Cross sectional study of childhood obesity and prevalence of risk factors for cardiovascular disease and diabetes in children aged 11-13. BMC Public Health. 2009;9(1):86. [Link] [DOI:10.1186/1471-2458-9-86]
15. Plotnikoff RC, Costigan SA, Williams RL, Hutchesson MJ, Kennedy SG, Robards SL, et al. Effectiveness of interventions targeting physical activity, nutrition and healthy weight for university and college students: A systematic review and meta-analysis. Int J Behav Nutr Phys Act. 2015;12(1):45. [Link] [DOI:10.1186/s12966-015-0203-7]
16. Eckardt K, Taube A, Eckel J. Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity. Rev Endocr Metab Disord. 2011;12(3):163-72. [Link] [DOI:10.1007/s11154-011-9168-2]
17. Abedi B, Ebrahimimonfared M, Sayyah M. Effects of aerobic versus resistance training on serum leptin and insulin resistance in healthy sedentary men. Hormozgan Med J. 2019;23(1):e86831. [Link] [DOI:10.5812/hmj.86831]
18. Parsian H, Eizadi M, Khorshidi D, Khanali F. The effect of long-term aerobic exercise on serum adiponectin and insulin sensitivity in type 2 diabetic patients. Pars J Med Sci. 2013;11(1):41-8. [Persian] [Link] [DOI:10.29252/jmj.11.1.6]
19. Elbalshy MM, Mohamed ME, Rahma AF. Effect of aerobic exercise on serum adiponectin and serum malondialdehyde (MDA) in type 1 diabetic patients. Eur J Prev Med. 2017;5(5):71-6. [Link] [DOI:10.11648/j.ejpm.20170505.14]
20. Parastesh M, Saremi A, Ahmadi A, Kaviani M. The effect of aerobic training on serum levels of adiponectin, hypothalamic-pituitary-gonadal axis and sperm quality in diabetic rats. Urol J. 2019;16(06):592-7. [Link]
21. Talebi Garekani E, Mohebbi H, Kraemer RR, Fathi R. Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat. Peptides. 2011;32(5):1008-12. [Link] [DOI:10.1016/j.peptides.2011.01.027]
22. Jashni HK, Mohebbi H, Delpasand A, Jahromy HK. Caloric restriction and exercise training, combined, not solely improve total plasma adiponectin and glucose homeostasis in streptozocin-induced diabetic rats. Sport Sci Health. 2015;11(1):81-6. [Link] [DOI:10.1007/s11332-014-0212-y]
23. Shepherd RE, Gollnick PD. Oxygen uptake of rats at different work intensities. Pflügers Archiv. 1976;362(3):219-22. [Link] [DOI:10.1007/BF00581173]
24. Lee S, Farrar RP. Resistance training induces muscle-specific changes in muscle mass and function in rat. J Exerc Physiol Online. 2003;6(2):80-7. [Link]
25. Sâmpelean D, Hănescu BI, Han AN, Adam M, Casoinic F. The prognosis of glycoregulation disturbances and insulin secretion in alcoholic and C virus liver cirrhosis. Romanian J Intern Med. 2009;47(4):387-92. [Link]
26. Amani Shalamzari S, Daneshfar A, Hassanzadeh Sablouei M, Fiatarone Singh MA, Kazemi A. The effect of aerobic training on tumor growth, adiponectin, leptin and ghrelin in mice models of breast cancer. Iran Red Crescent Med J. 2018;20(2):e13305. [Link] [DOI:10.5812/ircmj.13305]
27. Avazpor S, Fazel Kalkhoran J, Amini HA. Effect of 8 weeks of high intensity interval training on plasma levels of adiponectin and leptin in overweight nurses. Nov Biomed. 2016;4(3):87-92. [Link]
28. Mediano MF, Neves FA, Cunha AC, Souza EP, Moura AS, Sichieri R. Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of a small-volume, home-based exercise program. Clinics. 2013;68(8):1121-7. [Link] [DOI:10.6061/clinics/2013(08)10]
29. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7(8):941-6. [Link] [DOI:10.1038/90984]
30. Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Mol Med. 2008;14(11-12):741-51. [Link] [DOI:10.2119/2008-00058.Rabe]
31. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism. 2007;56(7):1005-9. [Link] [DOI:10.1016/j.metabol.2007.03.009]
32. Kobayashi J, Murase Y, Asano A, Nohara A, Kawashiri MA, Inazu A, et al. Effect of walking with a pedometer on serum lipid and adiponectin levels in Japanese middle-aged men. J Atheroscler Thromb. 2006;13(4):197-201. [Link] [DOI:10.5551/jat.13.197]
33. Hojbjerre L, Rosenzweig M, Dela F, Bruun JM, Stallknecht B. Acute exercise increases adipose tissue interstitial adiponectin concentration in healthy overweight and lean subjects. Eur J Endocrinol. 2007;157(5):613-23. [Link] [DOI:10.1530/EJE-07-0213]
34. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab. 2005;90(11):5970-7. [Link] [DOI:10.1210/jc.2005-0261]
35. Swift DL, Houmard JA, Slentz CA, Kraus WE. Effects of aerobic training with and without weight loss on insulin sensitivity and lipids. PLoS One. 2018;13(5):e0196637. [Link] [DOI:10.1371/journal.pone.0196637]
36. Behrens Jr CE. Effects of 12-weeks of aerobic exercise training on insulin sensitivity under energy balanced conditions in women: 1525 Board# 3 May 31 100 PM-300 PM. Med Sci Sports Exerc. 2018;50(5S):367. [Link] [DOI:10.1249/01.mss.0000536289.67351.5a]
37. Eriksson J, Taimela S, Eriksson K, Parviainen S, Peltonen J, Kujala U. Resistance training in the treatment of non-insulin-dependent diabetes mellitus. Int J Sports Med. 1997;18(04):242-6. [Link] [DOI:10.1055/s-2007-972627]
38. Das UN. Metabolic syndrome pathophysiology: The role of essential fatty acids. Hoboken: John Wiley & Sons; 2010. [Link]
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