Volume 23, Issue 4 (2020)                   mjms 2020, 23(4): 55-66 | Back to browse issues page

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Shatizadeh Malekshahi S, Ketabi K. Introduction of Chromosomally integrated human herpesvirus 6 and its clinical implications. mjms. 2020; 23 (4) :55-66
URL: http://mjms.modares.ac.ir/article-30-46355-en.html
1- Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University,Tehran, Iran
2- Department of Virology, Faculty of Medical Sciences, TarbiatModares University,Tehran, Iran , ketabi.kiana@yahoo.com
Abstract:   (330 Views)
Aims: Human herpes virus 6 (HHV-6) is a ubiquitous virus with a high rate of prevalence worldwide. In recent years, a new form of the virus genome has been identified called Chromosomally integrated HHV-6 (ciHHV-6). Further studies are required to elucidate the relation between ciHHV-6 and other clinical complications. The purpose of this study was to summarize the literature on different clinical aspects of the ciHHV-6 integration and its prevalevce in different communities.
Materials and methods: Search keywords include HHV-6, integrated genome, telomeric regions and integrated HHV-6. Scientific databases such as scopus, PubMed and google scholar with no specified start date were used for information collection.
Findings: About 1% of global populations are infected with ciHHV-6. Real-time PCR can be used to differentiate between ciHHV-6 and HHV-6 acute infection in which the viral load will be higher in ciHHV-6 compared to the acute infection. However, ciHHV-6 can be confirmed by evidence of one copy of viral DNA in hair or nail follicles. It has been shown that ciHHV-6 may disrupt the telomer stability.
Conclutions: To date, no treatment has been discovered to remove the viral genome from the host cells. Taken together, the integrated form of the HHV-6 genome could be linked to the various diseases, including heart and autoimmune diseases. But further studies are needed to find its association with other diseases in different geographic area.
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Article Type: Systematic Review | Subject: Virology
Received: 2020/09/27 | Accepted: 2021/02/19

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