Volume 25, Issue 3 (2022)
mjms 2022, 25(3): 36-39 |
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pishgooei F, Mehrazin S, Esmaeilpour K. Impact of Maternal Separation on Long-Term Potentiation and Synaptic Plasticity: Insights from Rodent Models. mjms 2022; 25 (3) :36-39
URL: http://mjms.modares.ac.ir/article-30-75227-en.html
URL: http://mjms.modares.ac.ir/article-30-75227-en.html
1- Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2- Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran ,khadijeh.esmaeilpour@yahoo.com
2- Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran ,
Abstract: (333 Views)
Maternal separation (MS) is a well-characterized model of early life stress, based on the postnatal disruption of the mother-infant interaction. Studies on rodents have demonstrated that MS, as an early adverse life event, leads to spatial memory deficits and lasting changes in brain plasticity. Here, we review data from animal studies regarding the impact of MS on long-term potentiation (LTP). Evidence shows that animal models are useful for evaluating the effects of MS on LTP. Overall, studies suggest that MS impairs LTP.
Keywords: Maternal separation, long-term potentiation, LTP, MS, Synaptic Plasticity, Brain, hippocampal granule cells, memory, BDNF, NMDA
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