Volume 27, Issue 3 (2024)
mjms 2024, 27(3): 19-29 |
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Abdollah Zadeh M, Abolnejadian F, Alisamir M, Reza Mirkarimi M, Torabizadeh M. Comparison of Efficacy of Nebulized Ventolin, Pulmicort and Normal Saline in Treatment of Children Under 2 Years Old with Bronchiolitis Admitted in Ahvaz Abuzar Hospital. mjms 2024; 27 (3) :19-29
URL: http://mjms.modares.ac.ir/article-30-78000-en.html
URL: http://mjms.modares.ac.ir/article-30-78000-en.html
Mahsa Abdollah Zadeh1 
, Farhad Abolnejadian 2, Mohsen Alisamir3 , Mohammad Reza Mirkarimi4 , Mehdi Torabizadeh5
, Farhad Abolnejadian 2, Mohsen Alisamir3 , Mohammad Reza Mirkarimi4 , Mehdi Torabizadeh5
1- Department of Pediatrics Pulmonology, Abuzar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Department of Pediatrics Pulmonology, Abuzar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,abolnejadfarhad@gmail.com
3- Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Department of Pediatric Pulmonology, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Pediatrics Pulmonology, Abuzar Children's Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran ,
3- Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Department of Pediatric Pulmonology, Abuzar Children’s Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract: (200 Views)
Background: Bronchiolitis is a common lower respiratory tract infection in infants. Apart from supportive care, no effective treatment for this disease has been identified so far. Accordingly, a double-blind randomized controlled trial was conducted on infants with a diagnosis of mild to moderate bronchiolitis. Material and Methods: Three clinical trial groups were designed, including Ventolin 0.15 mg/kg, Palmicort 125 mg twice a day, and normal saline nebulization every 4 hours. Clinical symptoms were monitored by asthma and allergy specialist daily, and the need for supplemental oxygen, recovery time from symptoms, and hospital days were recorded and compared between the three groups. Results: The results demonstrated that the frequency of oxygen requirement in both palmicort and normal saline groups was lower in compare to the ventolin group. But there was no significant difference between the three groups (P=0.765 and P=0.907, respectively). The duration of symptom improvement in the normal saline and palmicort group was significantly shorter than the Ventolin group (P=0.017). No significant difference was observed between the three groups of Ventolin, Pulmicort and normal saline during the treatment in terms of clinical score (P≥0.05). Conclusion: The obtained results showed that Ventolin or Palmicort nebulizer is not statistically better than normal saline for the treatment of children with bronchiolitis. Therefore, our results do not support the routine use of bronchodilators in the clinical setting for the management of mild to moderate forms of bronchiolitis in infants.
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