Volume 28, Issue 2 (2025)
mjms 2025, 28(2): 73-94 |
Back to browse issues page
Ethics code: IR.MODARES.REC.1403.031
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Nouri S. Therapeutic Potential of M2 Macrophage-Derived Exosomes in Regenerative Medicine. mjms 2025; 28 (2) :73-94
URL: http://mjms.modares.ac.ir/article-30-80564-en.html
URL: http://mjms.modares.ac.ir/article-30-80564-en.html
1. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. , soheilnouri.r@gmail.com
Abstract: (103 Views)
M2 macrophages and their exosome-derived products have therapeutic potential in regenerative medicine. M2 macrophages, characterized by their anti-inflammatory and tissue-repair functions, play pivotal roles in immune modulation, wound healing, and disease resolution. M2 macrophage-derived exosomes can modulate inflammatory responses, promote angiogenesis, and stimulate stem cell activity.
The review systematically examines their roles in diverse preclinical models, including diabetic fractures, periodontitis, neurodegenerative diseases, myocardial infarction, and chronic wounds. It addresses progress in bioengineering, such as combining M2-derived exosomes with biomaterials and scaffolds to improve targeted delivery and regenerative results. Although they show great potential, obstacles like exosome diversity, restricted scalability, and the need for standardized isolation techniques are recognized as hindrances to clinical application.
This review distinguishes M2 macrophage-derived exosomes as a promising acellular tool for personalized therapeutic applications and tissue repair by synthesizing existing literature and identifying promising directions for future research. It emphasizes the need for ongoing research to overcome technical and regulatory barriers to their successful translation to the clinical setting
The review systematically examines their roles in diverse preclinical models, including diabetic fractures, periodontitis, neurodegenerative diseases, myocardial infarction, and chronic wounds. It addresses progress in bioengineering, such as combining M2-derived exosomes with biomaterials and scaffolds to improve targeted delivery and regenerative results. Although they show great potential, obstacles like exosome diversity, restricted scalability, and the need for standardized isolation techniques are recognized as hindrances to clinical application.
Keywords: M2 Macrophages, M2 Macrophage-derived Exosomes, Regenerative Medicine, immunomodulation, tissue repair.
Article Type: Analytic Review |
Subject:
Immunology and Microbiology (General)
Received: 2025/04/27 | Accepted: 2025/05/12
Received: 2025/04/27 | Accepted: 2025/05/12
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |