Importance of SARA-COV-2 serological tests in diagnosis, vaccination and treatment

Document Type : Analytic Review

Authors
N. hajiahmadi 1
H. Soleimanjahi 2
T. bamdad 3
1 Ph.D. student, Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2 Professor, Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3 Associated Professor, Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract
SARS-COV-2, the latest member of Coronaviridea family as the cause of the recent global epidemic, has inflicted sever damages in different fields on most governments. Appropriate strategies such as identifying infected individuals and isolating them, trying to produce an effective vaccine, finding efficient treatment and making correct decisions in the social, economic and health fields are the current priorities of the world. Serological tests provide useful information in all of the above areas. In this article we will discuss the importance of performing SARS-COV-2 serological tests in diagnosis, vaccination, treatment and proper planning in the society.

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1. Soleimanjahi H, Habibian A, Farahmand Z, Khorrami S, Ketabi K, Rastegarvand N, Nasiri Z, Yamini A. Emerging Diseases in Coronaviruses COVID-19. 1st ed. Tarbiat Modares university. 2020; P:4-6. (Persian)
2. Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerging microbes & infections. 2020;9(1):727-32.
3. World Health Organization Coronavirus Diseases (covid19).
4. Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. Journal of virology. 2020;94(7):1-9.
5. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). Journal of general internal medicine. 2020; 35(5): 1545-9.
6. Rokni M, Ghasemi V, Tavakoli Z. Immune responses and pathogenesis of SARS‐CoV‐2 during an outbreak in Iran: Comparison with SARS and MERS. Reviews in Medical Virology. 2020;30(3): 1-6.
7. Wang C, Yu H, Horby PW, Cao B, Wu P, Yang S, et al. Comparison of patients hospitalized with influenza A subtypes H7N9, H5N1, and 2009 pandemic H1N1. Clinical infectious diseases. 2014;58(8):1095-103.
8. Jin Y-H, Cai L, Cheng Z-S, Cheng H, Deng T, Fan Y-P, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Medical Research. 2020;7(1):1-23.
9. Jacofsky D, Jacofsky EM, Jacofsky M. Understanding antibody testing for covid-19. The Journal of Arthroplasty. 2020; 199(3): 74-81.
10. Huang AT, Garcia-Carreras B, Hitchings MD, Yang B, Katzelnick LC, Rattigan SM, et al. A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease. medRxiv. 2020;4(14):1-47.

11. Lin Q, Zhu L, Ni Z, Meng H, You L. Duration of serum neutralizing antibodies for SARS-CoV-2: lessons from SARS-CoV infection. Journal of Microbiology, Immunology, and Infection. 2020; 3(15):1-3.
12. Wu L-P, Wang N-C, Chang Y-H, Tian X-Y, Na D-Y, Zhang L-Y, et al. Duration of antibody responses after severe acute respiratory syndrome. Emerging infectious diseases. 2007;13(10):1562.
13. Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, et al. Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clinical Infectious Diseases. 2020; 71(15): 778-785.
14. Liu L, Liu W, Zheng Y, Jiang X, Kou G, Ding J, et al. A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients. Microbes and Infection. 2020; 22(4-5): 206-211.
15. Sun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, et al. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerging Microbes & Infections. 2020(just-accepted):1-36.
16. Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clinical Infectious Diseases. 2020; 1-22.
17. Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, et al. Development and clinical application of a rapid IgM‐IgG combined antibody test for SARS‐CoV‐2 infection diagnosis. Journal of medical virology. 2020; 1-7.
18. GeurtsvanKessel CH, Okba NM, Igloi Z, Bogers S, Embregts CW, Laksono BM, et al. An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nature communications. 2020;11(1):1-5.
19. Okba NM, Müller MA, Li W, Wang C, GeurtsvanKessel CH, Corman VM, et al. Severe acute respiratory syndrome coronavirus 2− specific antibody responses in coronavirus disease patients. Emerging infectious diseases. 2020;26(7):1478.
20. Wang X, Guo X, Xin Q, Pan Y, Hu Y, Li J, et al. Neutralizing antibody responses to severe acute respiratory syndrome coronavirus 2 in coronavirus disease 2019 inpatients and convalescent patients. Clinical Infectious Diseases. 2020; XX(XX): 1-7.
21. Hashempour T, Ajorloo M, Bamdad T, Merat S, ZAER RH, Fakharzadeh E, et al. Development of a recombinant based ELISA using specific antibodies to F protein in HCV chronically infected patients-A seroprevalence study. 2010; 4(1): 1-6.
22. Iha K, Inada M, Kawada N, Nakaishi K, Watabe S, Tan YH, et al. Ultrasensitive ELISA Developed for Diagnosis. Diagnostics. 2019;9(3):78.
23. Kimball A, Hatfield KM, Arons M, James A, Taylor J, Spicer K, et al. Asymptomatic and presymptomatic SARS-CoV-2 infections in residents of a long-term care skilled nursing facility—King County, Washington, March 2020. Morbidity and Mortality Weekly Report. 2020;69(13):377.
24. Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. New England Journal of Medicine. 2020;382(10):970-1.
25. Long Q-X, Tang X-J, Shi Q-L, Li Q, Deng H-J, Yuan J, et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature medicine. 2020:1-5.
26. Lipsitch M, Kahn R, Mina MJ. Antibody testing will enhance the power and accuracy of COVID-19-prevention trials. Nature Medicine. 2020; 26: 814-821.
27. Schnurra C, Reiners N, Biemann R, Kaiser T, Trawinski H, Jassoy C. Comparison of the diagnostic sensitivity of SARS-CoV-2 nucleoprotein and glycoprotein-based antibody tests. Journal of Clinical Virology. 2020; 129:104544.
28. Liu W, Liu L, Kou G, Zheng Y, Ding Y, Ni W, et al. Evaluation of nucleocapsid and spike protein-based enzyme-linked immunosorbent assays for detecting antibodies against SARS-CoV-2. Journal of clinical microbiology. 2020;58(6): 1-7.
29. Walls AC, Park Y-J, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020; 181(2): 281-292.
30. Abbasi J. The promise and peril of antibody testing for COVID-19. Jama. 2020;323(19):1881-3.
Pathobiology Reserach
Volume 23, Issue 0
March 2021
Pages 89-97