Deep Brain Stimulation for Epilepsy

Document Type : Systematic Review

Authors
M. Rezaei
N. Heidari
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract
Novel antiepileptic drugs (AED) are now available. However, many epileptic patients still find the condition difficult to handle. Drug therapy does not work for about one-third of the cases and not all people who will benefit from surgery. The use of electric current as a treatment option has emerged since the late twentieth century. Inhibition of synapse activity is a way that low-frequency stimulation (LFS) prevents epileptic activity. It will enhance the endocytosis of AMPA-type glutamate receptors and activate calcineurin, thereby leading to long-term depression (LTD). High-frequency stimulation (HFS) also contributes to the control of epilepsy by increasing the membrane permeability of neurons. Nonetheless, the detailed mechanisms responsible for these effects are still unknown. More research is required to fine-tune electrical stimulation parameters and yield better results in epilepsy patient care.

Keywords

References
1. Theodore WH, Fisher R. Brain stimulation for epilepsy. Acta Neurochir Suppl. 2007; 97(Pt 2):261–72.
2. Hauser WA, Hesdorffer DH. Epilepsy: frequency, causes and consequences. New York: Demos Press; 1990.
3. Gross RE. Deep brain stimulation in the treatment of neurological and psychiatric disease. Expert Rev Neurother. 2004; 4(3):465–78.
4. Manahan-Vaughan D. Long-term depression in freely moving rats is dependent upon strain variation, induction protocol and behavioral state. Cereb Cortex. 2000; 10(5):482–7.
5. Bikson M, Lian J, Hahn PJ, Stacey WC, Sciortino C, Durand DM. Suppression of epileptiform activity by high frequency sinusoidal fields in rat hippocampal slices. J Physiol. 2001; 531(Pt 1):181–91.
6. D'Arcangelo G, Panuccio G, Tancredi V, Avoli M. Repetitive low-frequency stimulation reduces epileptiform synchronization in limbic neuronal networks. Neurobiol Dis. 2005; 19(1-2):119–28.
7. Durand DM, Bikson M. Control of neural activity by electrical fields: in vitro models of epilepsy. In: Luders HO, editor. Deep brain stimulation and epilepsy. London: Martin Dunitz; 2004. p. 67–86.
8. Durand DM, Jensen A, Bikson M. Suppression of neural activity with high frequency stimulation. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1624–5.
9. Gwinn RP, Spencer DD. Fighting fire with fire: brain stimulation for the treatment of epilepsy. Clin Neurosci. 2004; 4(1):95–105.
10. Kinoshita M, Ikeda A, Matsumoto R, Begum T, Usui K, Yamamoto J et al. Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes. Epilepsia 2004; 45(7):787–91.
11. Bragin A, Wilson CL, Engel J. Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents. Epilepsia 2002; 43(s5):81–5.
12. Hoffman RE, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am J Psychiatry. 2002; 159(7):1093–102.
13. Wyckhuys T, Geerts PJ, Raedt R, Vonck K, Wadman W, Boon P. Deep brain stimulation for epilepsy: knowledge gained from experimental animal models. Acta Neurol Belg 2009; 109(2):63–80.
14. Wyckhuys T, Raedt R, Vonck K, Wadman W, Boon P. Comparison of hippocampal Deep Brain Stimulation with high (130Hz) and low frequency (5Hz) on afterdischarges in kindled rats. Epilepsy Res 2010; 88(2-3):239–46.
15. Ebert U, Ziemann U. Altered seizure susceptibility after high-frequency transcranial magnetic stimulation in rats. Neurosci Lett 1999; 273(3):155–8.
16. Gori B, Pereyra M, Toibaro L, Brescacin C, Battaglia G, Pastorino J et al. Hippocampal High-Frequency Stimulation Inhibites the Progression of Rapid Kindling-Induced Seizure in Rats. NM 2013; 04(02):71–6.
17. Child ND, Benarroch EE. Anterior nucleus of the thalamus: functional organization and clinical implications. Neurology 2013; 81(21):1869–76.
18. Yu T, Wang X, Li Y, Zhang G, Worrell G, Chauvel P et al. High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans. Brain 2018; 141(9):2631–43.
19. Lin CH, Lee CC, Gean PW. Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory. Mol Pharmacol. 2003; 63(1):44–52.
20. Rosenzweig ES, Barnes CA. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog Neurobiol. 2003; 69(3):143–79.
21. Weiss SRB, Li X-L, Rosen JB, Li H, Heynen T, Post RM. Quenching: inhibition of development and expression of amygdala kindled seizures with low frequency stimulation. Neuroreport 1995; 6(16):2171–6.
22. Kemp N, Bashir ZI. Long-term depression: a cascade of induction and expression mechanisms. Prog Neurobiol. 2001; 65(4):339–65.
23. Straube T, Frey JU. Time-dependent depotentiation in the dentate gyrus of freely moving rats by repeated brief 7 Hz stimulation. Neurosci Lett. 2003; 339(1):82–4.
24. Huang CC, Liang YC, Hsu KS. A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses. J Neurosci. 1999; 19(22):9728–38.
25. Dostrovsky JO, Lozano AM. Mechanisms of deep brain stimulation. Mov Disord 2002; 17 Suppl 3:S63-8.
Pathobiology Reserach
Volume 25, Issue 3
April 2022
Pages 32-35