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Mehrabi M, Mirshahi M, Pourfathollah A. Introduction Sandwich Direct ELISA screening test in order to Breast cancer Diagnosis. mjms 2010; 9 :45-53
URL: http://mjms.modares.ac.ir/article-30-11966-en.html
Introduction Sandwich Direct ELISA screening test in order to Breast cancer Diagnosis
Mohammad-Reza Mehrabi1 , Manuchehr Mirshahi 2, Ali-Akbar Pourfathollah3
1- M.Sc. Student, Department of Hematology, Tarbiat Modares University, Tehran, Iran.
2- Assistant Professor, Department Biochemistry, Tarbiat Modares University, Tehran, Tran.
3- Full Professor, Department of Immunology, Tarbiat Modares University, Tehran, Iran.
Abstract:   (4999 Views)
Introduction: Breast cancer is one of the provalent cancers in the world. This cancer as well as other solid tumors, in the course of its development has phases in this order: Epithelial Dysplasia, Carcinoma Insitu, Invassiveness and metastasis. Breast cancer Diagnosis is generally made with pathology methods. In this survey, measuring Angiostatin (which is one of the most important and potent angiogensis inhibitor) in random urine as a noninvassive method was introduced to diagnose the disease. Materials and Methods: In this assay, random urine samples of 15 Breast cancer patient and 15 control urine samples were obtained, and assayed with improved sandwich direct ELISA. Results: Obtained result in statistical T-Test (Pvalue<0.03) showed significant correlation between urine angiostatin and breast cancer, that has coordinace with the result of patients sample pathology. Discussion: Angiostatin dosage in urine of patients of breast cancer is a good marker of non invassive diagnosis.
Keywords: Breast Cancer, ELISA, Angiogenesis, Angiostatin, Solid tumors
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Received: 2006/07/12 | Accepted: 2006/08/25
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